Dr. Ashaq Hussain Parrey
Rheumatology
The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.
Answered by
Medically reviewed by
Patient's Query
Hello doctor,
Could you review my lab results to assess the likelihood of an autoimmune condition? My ANA titer is 1:1280 (homogeneous), and my RNP score has been 1.2 and 1.3 on two tests. My rheumatologist believes it is a false positive with benign antibodies, even at this high titer. Are they correct or incorrect in their assessment?
I am experiencing symptoms like joint instability, frequent joint cracking (wrist, ankles, shoulders, knees), sometimes accompanied by pain (especially in the ankles). I also have persistent forearm and wrist stiffness and occasional pain. I had a one-week episode of extreme fatigue that sent me to the emergency room, and I have lost 25 pounds in two months. There is also chronic muscle inflammation, causing a swollen throat. The rheumatologist confirmed joint thickening in my wrists but did not examine my ankles. My hands become very cold, and lock up in a cold room. Please help.
Thank you.
Hi,
Welcome to icliniq.com.
I read your query and understand your concern.
After reviewing the reports (attachments removed to protect the patient's identity), two key points stand out: a strongly positive ANA (antinuclear antibody) and the presence of arthritis (stiff joints). ANA results of this magnitude are rarely false positives, and the existence of arthritis suggests a diagnosis of undifferentiated connective tissue disease. To further differentiate, I suggest conducting an ENA (extractable nuclear antigens profile) is essential. Additionally, a nail fold capillaroscopy, a procedure examining the tiny blood vessels (capillaries) at the base of the fingernails or toenails using a special microscope will provide valuable insights.
I hope this helps.
For further inquiries, feel free to consult me at icliniq.com.
Thank you.
Was this conversation helpful?
Same symptoms don't mean you have the same problem. Consult a doctor now!
Rheumatology
Related Questions
Stress Fractures- Causes, Symptoms, Prevention, and Management
Effects of Maternal Autoimmune Disorders on Pregnancy and Fetal Health
Gonococcal Arthritis - Bacterial Inflammation of the Joints
Stress Fracture of Leg - Causes, and Treatment
Oral Health and Autoimmune Disorders - An Overview
Celecoxib - Uses, Side-Effects, and Precautions
Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.
This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy
