Patient's Query
Hello doctor,
My brother has done a muscular biopsy. I want to know whether the general functions of the mitochondria have been checked and verified in this muscular biopsy. In the hospital, they have checked the muscular biopsy and they are as follows: ATPases (9.4, 4.63, 4.35), menadione, succinate dehydrogenase, DNPH, phosphorylase, adenylate deaminase and cytochrome oxidase.
Hello,
Welcome to icliniq.com.
The diagnosis of mitochondrial disease was based on the presence of characteristic ragged red fibers (RRF) in more than 2 % of muscle fibers in the muscle biopsy (attachment removed to protect patient identity). RRFs are not pathognomonic of mitochondrial diseases, but can also be seen in other conditions like dystrophies and dermatomyositis. The usual stains used in the diagnosis of mitochondrial disorders are:
a) Gomori trichrome stain.
b) Succinate dehydrogenase stain.
c) Cytochrome oxidase.
d) ATPase (4.3, 4.6, 9.4).
I agree that with the list of enzymes provided mitochondrial pathology has been ruled out.
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Answered byDr. Ambekar Sudheer
Medically reviewed byiCliniq medical review team
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