Bone Marrow Aspiration

The procedure done to collect a sample of the bone marrow, which is the soft tissue core of large bones, is called bone marrow aspiration. The sample is collected by inserting a hollow needle through the skin and into the bone. This procedure is done to diagnose conditions like anemia, blood cancer, hemochromatosis, infections like tuberculosis, and other bone marrow diseases.

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My wife has been advised bone marrow test after she developed an allergy during the blood transfusion for low hemoglobin. Please help.

Query: Hello doctor, My wife aged 36 with low hemoglobin got her hemoglobin and platelet increased. But after two months, she had vomiting and developed jaundice, and the hemoglobin got reduced again. The doctors advised two bottles of blood transfusion, but after 75 % of the blood was transfused, she got ...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I read your query and can understand your concern. I have noted that your wife's hemoglobin level is not increasing with iron treatment and decreasing for two months according to the history provided. Moreover, she had suffered from jaundice as well. So, I suggest you ...  Read Full »

I am a 26-year-old girl with a history of idiopathic thrombocytopenic purpura and am taking medications for it. Can I get pregnant?

Query: Hello doctor,I am a 26-year-old girl who suffered from idiopathic thrombocytopenic purpura, three months ago. I was under treatment for the next three months with Corticosteroids and Imuran (Azathioprine). After three months doctor did not give me any treatment as my platelet count was normal. Now I...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I went through your query and understood your concern. The cause for your reduced platelet count was not clear. If no cause is found then it could be idiopathic thrombocytopenic purpura (ITP). A bone marrow aspiration study can be done to confirm it. This disease sho...  Read Full »

How to manage microcytic hypochromic anemia with thrombocytopenia?

Query: Hi doctor, My partner was admitted to the hospital for low platelet count, and she was asymptomatic. They did a blood transfusion and gave corticosteroids. There was no improvement on her platelet level. The doctor suggested me to consult a hematologist. On her recent reports, her platelet count wa...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to I have gone through the attachment (attachment removed to protect patient identity). Her platelet count is low in the manual as well as in cell counter. So infective etiology has to be ruled out first. If there is no sign of any infection, then ultrasonography abdomen has...  Read Full »

My 8-year-old son is diagnosed with a low platelet count. What to do?

Query: Hello doctor, My 8 year old son was diagnosed with a possible bone marrow failure during monitoring for low platelets when he was three years old. His biopsy showed areas of 20 % cellularity. Last year his counts were WBC 13.8, RBC 4.83, hemoglobin 13.5 g/dL, hematocrit 39.3, MCV 81.3, MCH 27.9, MC...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to You had mentioned the history of bone marrow failure at three years of age, but the cause and workup done at that time are not mentioned here.Temporary viral infection like parvovirus can lead to temporary bone marrow suppression.In a child, if platelet count remains low ...  Read Full »

The reports of bone marrow aspiration and biopsy differ. How?

Query: Hi doctor,Bone marrow aspiration twice showed hypercellular bone marrow with overgrowth of WBC and megakaryocytes with all stages of maturing including micromegakaryocytes. But at the same time, the second BMA during bone marrow biopsy showed normocellular bone marrow. Is something like that possibl...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to You have not mentioned the age of the patient, peripheral smear, and CBC (complete blood count) findings. You have mentioned that bone marrow was showing overgrowth of the WBC (white blood cells) and micromegakaryocytes. So, it is a myeloproliferative condition. ...  Read Full »

Can heavy menstrual bleeding cause anemia?

Query: Hello doctor,I have been suffering from anemia for over 12 years now. I am very sure that within this time frame, my hemoglobin level has never been higher than 10 g/dL. Recently, my hemoglobin was at 7.1 g/dL. I have seen many doctors and have informed them of a family history of a kidney disease, ...  Read Full »

Dr. Prasad Eswaran

Answer: Hello, Welcome to Can you forward your hemoglobin electrophoresis report to me? For more information consult a hematologist online -->  Read Full »

BMA for APL shows 3% on FISH RARA. Is it necessary to start chemo or ATRA again?

Query: Hi doctor, My husband was diagnosed with APL before six years. He underwent treatment by following the pethema protocol for APL. After consolidation phase, BMA revealed there is still 7% of PML Rara using fish rara test while negative on cytogenetics. His doctor proceeded to his maintenance phase ...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to Sorry to hear about your husband's diagnosis. He is having acute promyelocytic leukemia cancer and it is considered among favorable outcome leukemia. After starting chemotherapy complete remission includes less than 5% blast in bone marrow aspirate, ANC more then 1...  Read Full »

Can DPT vaccine cause neutropenia?

Query: Hi doctor, My son is 15 years. He got his DTaP vaccine two weeks ago and had CBC 20 days later. All came well except neutrophil count, which came back as 800 and total WBC 2500. We are going to repeat the test tomorrow. Can the vaccine be the cause for the neutropenia? And if so, how long will it ...  Read Full »

Dr. Prakash H. M

Answer: Hi, Welcome to Based on your query, my opinion is as follows: I doubt the vaccine could be the cause of neutropenia (neutrophil count less than normal). Though it can take place in some case like Influenza virus vaccine, but with DTP (diphtheria, tetanus and pertussis) have not bee...  Read Full »

How to find the stage of multiple myeloma?

Query: Hi doctor,My 97-year-old mother, who is in a nursing home, is more tired and feeling unwell. A blood test has shown she has likely got multiple myeloma. She had left-sided paralysis from a stroke six years ago. She cannot speak, and she is slow in understanding and writing, but she has no dementia. ...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hi, Welcome to Sorry to hear about your mother's condition. I have read all the test values that you have mentioned. From which, I can see that her total protein is high and albumin is low with elevated gamma globulin. Immunofixation electrophoresis is the best test to detect p...  Read Full »

Does an increased WBC count in my child after an infection suggest cancer?

Query: Hi doctor, My son turned one two months ago. He was last sick two months ago for about a week. He had some standard vaccinations and a routine CBC to check for lead level and anemia. The CBC came back with high WBC and high platelets. His pediatrician was not concerned and said it could be from a re...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to It is good to see that you are aware of your child's health. I have seen the reports (attachment removed to protect patient identity). Let me give you my opinion. Do not directly conclude it as a malignancy, especially leukemia. In the peripheral smear, no blast cells...  Read Full »

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