What could be the reason for the high CA-125 and CEA value in a 56-year-old woman?

Question

Hello doctor,

My aunt is 56 years old. She has 24 to 25 mm endometrial thickness with internal vascularity. Her CA-125 value is 50.1 units/L, and her CEA is 6.4 µg/L. I think she has reached menopause because her FSH is high (91 IU/L), and she has post-menopausal bleeding. During a physical examination, a solid mass was felt beneath the vagina. She also has low hemoglobin, and her pap smear test is negative. What is the most likely cause? And what is the best course of treatment and diagnosis? Because she also has other co-morbidities like epilepsy, blood pressure, and varicose veins. Currently, she is on Metoprolol, Tegretol, and Folic acid.

Answer 1

Hello,

Welcome to icliniq.com.

I have gone through your history and understand your concerns. Your aunt's symptoms are suggestive of hormonal imbalance due to her age, or it can be due to the menopausal stage. You must go for laparoscopic hysteroscopy dilation and curettage and send tissue for biopsy to rule out carcinoma.

There is a possibility that polyps or mass should be ruled out with the help of an MRI (magnetic resonance imaging) pelvis.

Regards.

Answer 2

Hello,

Welcome back to icliniq.com.

MRI (magnetic resonance imaging) pelvis can help to rule out if there is mass, but for hormonal imbalance, hysteroscopy and biopsy are recommended.