Q. What can cause chronic fever, body aches, and diarrhea?

Answered by
Dr. Utkarsh Sharma
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 19, 2022

Hello doctor,

I have been getting a fever every other night or once a month during the night. I have also been getting sick with body aches and fevers with diarrhea. The labroratory ran a complete blood test, and on the SPEP test, they noticed a spike in the gamma region. They performed an immunofixation electrophoresis, and a comment mentions biclonal IgG Kappa. I wanted clarification on what it means. My doctor said he would call me regardless of the results, but I haven’t heard back yet.



Welcome to

I understand your concern. Biclonal gammopathy involves the presence of 2 or more M-proteins in serum or urine. It may occur due to the production of monoclonal immunoglobulins from two plasma cell clones or two monoclonal proteins from a single plasma cell clone. Monoclonal gammopathy of undetermined significance is (MGUS) is a precursor of multiple myeloma and is present in 3 to 4 percent of the population above 50 years of age. Of this population, 5 to 6 percent have biclonal gammopathy, which has a better prognosis. For further evaluation, you should get a complete blood count, which will reveal your Hb (hemoglobin) levels that might be low causing body ache and tiredness. A radiological examination to find any plasma cell-associated bone lesions and a kidney function test are also required. A bone marrow aspirate and biopsy might be necessary if clinically indicated.

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