HomeAnswersNephrologychronic kidney diseaseMy 83-year-old mother has been suffering from chronic kidney disease for two years, and her creatinine levels keep fluctuating. Please suggest medications.

How to manage fluctuation of creatinine levels in a 83-year-old female with chronic kidney disease?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

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Published At December 11, 2023
Reviewed AtMarch 15, 2024

Patient's Query

Hello doctor,

My 83-year-old mother was diagnosed with CKD G4 two years ago when her hemoglobin levels dropped significantly. She has not had any prior high blood pressure or diabetes issues. Some of the observed side effects include leg cramps, and a leg scan revealed calcification and narrow arteries, though it is unclear if these are related. She also has cytopenia and anemia, with her normal hemoglobin levels ranging between 8 to 9 grams percent. She has been consistently taking CKD (chronic kidney disease) medication for over a year, resulting in her creatinine levels fluctuating between 2 mg/dL and 2.3 mg/dL. However, her recent creatinine level has increased to 2.4 mg/dL, and other parameters, such as hemoglobin, have dropped despite regular injections.

I am seeking a second opinion to determine if there is a need to add any medication to reduce her creatinine levels, as I could not find any specific medication for creatinine reduction. I am also interested in a healthy CKD-friendly weekly vegetarian diet plan to help her gain strength while managing toxins and keeping creatinine and other parameters in check. Her current medications include:

  1. Tablet Cilacar 10 mg twice daily.
  2. Tablet Auxisoda-EC 500 mg three times daily.
  3. Tablet ME-12 once daily.
  4. Tablet Geroz LP once daily.
  5. Injection Darbitop 40mg once every 10 days.

I would appreciate any diet plan recommendations or references you can provide.

Thank you for your assistance.

Answered by Dr. Yash Kathuria

Hello,

Welcome to icliniq.com.

I understand your concern.

I understand your concern about your mother's CKD (chronic kidney disease) status. Regarding her creatinine level, it should be noted that creatinine levels can fluctuate due to various factors such as changes in muscle mass, dietary choices (including non-vegetarian diets), acute kidney injury caused by dehydration, nephrotoxic drugs, and infections. To consider a creatinine level increase significant, there should be a 0.3 mg/dl rise compared to the previous value. In your mother's case, it appears to be less than that.

To help maintain her creatinine level, I would suggest the following:

  1. Avoid non-vegetarian food.
  2. Ensure she stays adequately hydrated, as dehydration can affect creatinine levels. Aim for a sufficient daily water intake.
  3. Prevent urinary tract infections through proper hygiene practices.
  4. Limit her protein intake to between 0.02 to 0.03 ounces per pound of body weight per day, focusing on vegetarian sources.

Please provide information about her daily water consumption, daily urine output, and whether she has any leg swelling. This information will help me provide you with a more specific diet plan.

I hope this information will help you.

Thank you.

Patient's Query

Hi doctor,

Thank you for your response.

As mentioned in the description above, my mother is a lifelong vegetarian, so there is no question of a non-vegetarian diet. She has been following the diet chart given by a dietitian two years ago when she was diagnosed with CKD. Her water intake ranges from 4 to 6 cups, depending on the season. Her urine output is normal, occurring 4 to 5 times in a 24-hour period. There is no swelling in her legs, and she feels physically fine, except for the dietary restrictions (reduced salt, sugar, and leached vegetables). Otherwise, she does not report any other issues.

Given her overall condition and the rise in creatinine levels, we are concerned about whether she may need medication to address this issue. Could you recommend any additional medications to be added to her current prescription, as listed above? Additionally, I would greatly appreciate it if you could provide a comprehensive diet chart suitable for an elderly individual like her.

Thank you and regards.

Answered by Dr. Yash Kathuria

Hello,

Welcome back to icliniq.com.

I understand your concern.

Regarding medication, considering her low protein diet, an option to compensate for essential amino acids is alpha-ketoanalogue. The recommended dosage is one tablet of 200 mg per 5 kg of body weight. You can start with two tablets every eight hours and gradually increase to three tablets every eight hours. This medication has shown the potential to slow down kidney deterioration. It is essential to maintain her hemoglobin levels between 9.5 to 11. Please provide her current diet chart, including calorie intake and details of her consumption of fruits and vegetables. This information will help me create a more precise diet plan.

I hope this information will help you.

Thank you.

Patient's Query

Hi doctor,

Thank you for the reply.

The medicine is Alpha Ketoanalogue 200 mg, twice a day initially, and then thrice a day. Am I correct? Is this the dosage to be given? Will this also help reduce creatinine, or will some other medicine be added? She is given a Derbitop 40 mg injection once in 10 days for hemoglobin. Is anything else to be added here to maintain the hemoglobin level? She does not have a diet chart as such. She is given a sample chart, which I have attached here, but she needs a proper diet plan for seven days a week, which takes care of her intake appropriately. Some instructions are also given, as follows. Keep control of sugar level.

Thanks.

Answered by Dr. Yash Kathuria

Hi,

Welcome back to icliniq.com.

I understand your concern.

Alpha keto analogs, two tablets of 200 mg each, have to be given. There is no other drug that may prevent or reduce the creatinine level. Only the prevention of dehydration and infection may reduce the progression of CKD (chronic kidney disease). Her iron stores are good, so she needs darbepoetin to maintain hemoglobin between 9.5 and 11. Now, about her diet, the diet chart that you provided is good enough. I am adding some more vegetables that she can take.

  1. Brinjal, bitter gourd, fenugreek, peas, lady finger, capsicum, and jackfruit.
  2. Apples, pineapples, grapes, guava, papayas, and pears can be taken as fruits.
  3. Using multigrain flour, including ragi, bajra, and sorghum, is best for chapati.
  4. You may apply a bit of ghee to the chapati to maintain the fat content in your diet.
  5. Protein powder can be used in two scoops twice daily to help with protein requirements.
  6. Four almonds and two walnuts can be taken daily.
  7. Vegetarian diet itself is very helpful in preventing the progression of kidney disease.
  8. The only thing to remember is dehydration, infection, and kidney toxic drugs like painkillers and antibiotics may cause disease progression very fast, so that needs to be prevented.
  9. Hygiene and adequate water consumption have to be maintained.
  10. Salt intake is less than 5gm per day.
  11. Once in 10 days, she may consume food of her choice because restricting food very strictly in kidney disease may depress the person.

I hope this helps.

Thanks.

Patient's Query

Hi doctor,

Thank you for the reply.

The only thing I need to ask is the consumption of water. In summer, she consumes 1.5 liters of water and takes 0.5 liters to 0.8 liters; in winter, she consumes a little more than 0.5 liters. She also has one cup of curd for lunch once a day. I hope that is fine. Can she take lassi or buttermilk, and should that count in the water intake quantity? Generally, what should her water consumption be in a day - summer, monsoon, and winter? This should complete all my queries, and I once again convey my heartfelt gratitude.

Thanks.

Answered by Dr. Yash Kathuria

Hello,

Welcome back to icliniq.com.

I understand your concern. Water intake depends on the CKD (chronic kidney disease) stage and urine output in kidney disease. If you can measure her 24-hour urine output, that would be good. She can take 300 to 500 ml more than her urine output. Water intake must also be maintained above one liter in winters and monsoons. Yes, she may take lassi, which should be part of her total daily water intake.

I hope this information will help you.

Thanks.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Yash Kathuria
Dr. Yash Kathuria

Family Physician

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