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HomeAnswersInternal Medicinechronic kidney diseaseMy wife is a kidney patient and on Pantoprazole for stomach issues. Is it harmful to the kidneys?

Is Pantoprazole not ideal for kidney patient?


The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Vinodhini J.

Published At August 12, 2020
Reviewed AtOctober 14, 2022

Patient's Query

Hello doctor,

My wife is a kidney patient and she has acid reflux, which causes chest tightness and feels like a lump in the throat. She was given GI cocktail and feels some relief. Later they prescribed Prantopozole 40 mg. We are wondering whether she can try Pepcid or Gelusil or Prilosec as we are worried about the side effects of Pantoprazole that might affect the kidneys. Please advise.


Welcome to icliniq.com.

Pantoprazole is used clinically to reduce gastric acid secretion. Pantoprazole can relieve pain in patients with duodenal ulcers and improve nausea, bloating, acid reflux, belching, and other ulcer-associated symptoms.

The bioavailability of Pantoprazole is >75% and it is metabolized primarily in the liver. Approximately 80% of Pantoprazole metabolites are excreted by the kidneys and retained in the stool.

The plasma clearance rate is 11 l/h, as so Pantoprazole has relatively fewer adverse side effects compared with other pharmacological agents. Side effects include occasional dizziness, insomnia, drowsiness, nausea, diarrhea, constipation, rash, muscle pain, arrhythmia, increased aminotransferases, and decreased granulocytes.

Investigations to be done

Regularly monitoring kidney function.

Treatment plan

Continue the Pantoprazole as prescribed.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Gohel Harshul Maheshbhai
Dr. Gohel Harshul Maheshbhai

General Practitioner

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