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HomeAnswersInternal Medicinedrug interactionsCan Zoloft and Propranolol be taken together?

Will Propranolol alter the drug metabolism of Sertraline?

Will Propranolol alter the drug metabolism of Sertraline?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At February 10, 2018
Reviewed AtJune 29, 2023

Patient's Query

Hello doctor,

I took Zoloft and Inderal and noticed some interaction. I would like that to be explained to me. Is it safe to take both Propranolol oral and Sertraline oral at the same time? Will Propranolol oral increase the level or effect of Sertraline by altering drug metabolism?

Answered by Dr. Sadaf Mustafa


Welcome to icliniq.com. Zoloft (Sertraline) and Inderal (Propranolol) are metabolized through same pathway in the liver. Zoloft reduces the metabolism of Inderal resulting in higher levels of Inderal in the body. What that means for you is that the dose of Inderal should be reduced while you take Zoloft. Otherwise you will be at risk of hypotension, heart block and other complications. Remember you cannot just discontinue either of these medications both Zoloft and Inderal should be tapered off under a physician supervision. How much Inderal are you taking and how much Zoloft are you planning to take? Please let me know so that I can be of further assistance. Thank you.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Sadaf Mustafa
Dr. Sadaf Mustafa

Internal Medicine

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