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HomeAnswersObstetrics and GynecologyestradiolShould I use Progesterone cream for elevated estradiol values?

I have irregular periods with elevated cortisol and estradiol. Please help.

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Vinodhini J.

Published At January 11, 2021
Reviewed AtSeptember 13, 2023

Patient's Query

Hello doctor,

I am a 50-year-old female in good health. I am not on any medication, and I eat well. My height is 5'4" and weight 140 pounds. I have an irregular period, fatigue, cyclical migraine headaches, anxiety, panic attacks, and dry eyes. My basal temperature does not indicate ovulation, and the blood report came back with low vitamin D, high cortisol 22, high estradiol 613. I was on the third day of my cycle. Is this estrogen dominance, and should I use progesterone cream?

Answered by Dr. Richa Agarwal

Hi,

Welcome to icliniq.com.

Three things are important in your case-

1) High cortisol.

2) High estradiol.

3) Low vitamin D.

The most common cause of high-level cortisol is Cushing syndrome (pituitary adenoma) and stress. Get an MRI to rule out pituitary adenoma. Release your stress with the change in your lifestyle and diet. High estradiol mainly occurs during perimenopausal age and with a low progesterone level. Use progesterone cream in high doses of 400 mg/ day in two divided doses. Low vitamin D occurs in both the above conditions, so get direct sunlight exposure. You can use cod liver oil, fish, and cholecalciferol sachet. Your HbA1c level is also high. It indicates you are in the prediabetic stage. So take care of your blood sugar levels. So, in my opinion, you should consult a good endocrinologist and take treatment accordingly.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Richa Agarwal
Dr. Richa Agarwal

Obstetrics and Gynecology

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