What does the biopsy report from my colonoscopy signify?

Hello,

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Thank you for your query. I understand your concern. Your biopsy report is inconclusive and of little help in reaching a specific diagnosis. However, the chronicity and clinical symptoms you have described lead to the differentials between inflammatory bowel disease and indeterminate colitis. Laboratory investigations are non-specific, but the following tests will aid in diagnosing IBD (inflammatory bowel disease). IBD is a complex disease involving complex immune mechanisms, and there are remissions and bouts in tandem. So I suggest you to do the following investigations. Check ESR (erythrocyte sedimentation rate). Check CRP (C-reactive protein) levels. Check fecal calprotectin levels. Check ANCA (antineutrophil cytoplasmic antibodies) tests. I hope this has helped you. Thank you.

Hello,

Welcome back to icliniq.com.

Too high levels of fecal calprotectin will favor IBD. ANCA positivity will also favor IBD; raised ESR and CRP are too non-specific. Now intestinal tuberculosis can be ruled out on account of the biopsy description. A malignancy is highly unlikely at this stage as biopsy reveals no such features, and there is no wall thickening or discrete mass. Undergoing a USG (ultrasonography) and CT (computed tomography) would have been better, though. If you respond to the immunomodulator drugs, the diagnosis is confirmed, and other entities are automatically ruled out. I hope this has helped you. Thank you.