What is the cause for CRP (C-reactive protein) value rise in COVID-19 patients?

Q. Why did my brother's CRP level rise rapidly after COVID infection?

Answered by
Dr. Muhammad Zubayer Alam
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jun 23, 2021 and last reviewed on: Jul 17, 2023

Hi doctor,

My brother was tested positive for COVID and was under home isolation. His computed tomography (CT) score on Sunday morning was 10/25, progressive, and C-reactive protein (CRP) was 10. The next day he developed a 1020F fever, and we admitted him to the hospital. CRP score at the time of admission was 9.00 mg/dL. The medication started with Methylprednisolone 200 mg. On the following morning, CRP was 10.80 mg/dL, and the doctor increased the dosage to 500 mg in the morning and evening. Today the CRP was 9.8 mg/dL. Also, his oxygen levels are consistent at 98%. Could you help us in understanding the situation?



Welcome to icliniq.com. Thank you for the query. I can understand your concern. CRP (C-reactive protein) is an acute-phase protein. During infectious or inflammatory disease states, CRP levels rise rapidly within the first six to eight hours and may peak at a level of up to 35.00 to 40.0 mg/dL after 48 hours and may remain at the peak for one to five days. At the initial stage of your brother's COVID infections, viral loads may increase, and the ongoing inflammation process may rise too; for that reason, his CRP may be raised too. But after starting tablet Methylprednisolone, his CRP has declined because tablet Methylprednisolone can reduce inflammation. As inflammation begins to fall due to administration, CRP also decreases. HRCT (high resolution computed tomography) of the chest should be done to exclude COVID pneumonia. In the case of COVID pneumonia, the doctor should start antiviral medications. As your brother's oxygen saturation rate persists at 98%, his respiratory status is fine now. Take care. In case of any other query, ask me.

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