Am I safe if HIV DNA and RNA PCR are negative at 3 months?

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The replication of the virus has no relationship in the detection of the virus. If the virus is present in the body, the immune system will detect it, and start defending the body by producing antibodies. This procedure does not need any replication of the virus. It just needs a virus in the body.

So, if the fourth-generation test is negative by three months and six months, then you are negative. No need to worry about them.

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PCR test is quantitative and qualitative. Quantitative tests are used to monitor treatment. It measures, copies of virus present in the body per ml. If you get tested for qualitative PCR, it detects the presence of at least a single particle of the virus.

So, most times DNA PCR detects qualitative test, and it can detect HIV as early as seven days after possible infection. So, a test during the third month can conveniently rule out HIV 2 infection and no relationship on the growth potential of the virus because it can detect just a single copy of the virus.

HIV 1 grows by 10⁴ copies per ml of blood by three weeks and HIV 2 grows by 10³ copies per ml of blood. HIV 2 differed by secondary replication that is it follows the normal pattern of growth and replication initially along with HIV 1 but after six months, the growth will be reduced but by then both antigens and antibody tests will be conclusive. So, finally, you are negative for HIV 2. Consider being conclusive.