Will IVF help in avoiding chromosomal abnormality in future pregnancy?

Hello,

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1. As far as the subserous nature of the fibroid is concerned which is around 7cm x 6 cm, it per se is not going to have an effect or cause hindrance in conception but it is likely that it can cause problems during the pregnancy and in the late third trimester due to abdominal pain. So, it is advisable that it should be removed anyways as the size is a concern here and can cause incoordinate uterine contractions during labor later and also chances are that it would further grow under estrogen effect. Hence better get it removed.

2. As the fetus showed triploidy XXX G banded metaphase, which as per the mother's report, she has high chances of replication of similar results in future pregnancies as well which may not be compatible with life and likely missed abortions may occur in future. Hence, it is suggested that both of you should try for an IVF (in vitro fertilization) with ovum and sperm harvesting and in vitro fertilization of the egg by your sperm and subjecting the embryos to preimplantation genetic screening with FISH (fluorescence in situ hybridization) technique or PCR (polymerase chain reaction) or comparative genomic hybridization (CGH), before selecting the embryo for transplanting into the uterus.

Though the frequency of G banded metaphase telomeric association is high for 1, 3, 16 and X chromosome, the chances of the fetus getting triploidy are very high. Another best option for you as a couple would be to opt for a donor egg from another woman which can be fertilized in vitro by your sperm and then the embryo after pre implantation genetic screening can be implanted in your wife's womb to improve the chances of having a healthy conception.

I hope this helps.