Why my mother has got typhoid for the 12th time?

Hello,

Welcome to icliniq.com. First, I would like to know how she was diagnosed with typhoid. Since you know that culture is the gold standard I would be interested in seeing a blood, stool, bone marrow or any sort of culture which was done to diagnose her with Salmonella typhi. If this is a culture proven Salmonella typhoid, I would suggest looking for a source that is harboring the infection. The most common being endocarditis, splenic abscesses, liver abscesses and arthritis or hardware store and bone marrow involvement. It would be helpful to know if your mom is having any issues with chest pain, palpitations, shortness of breath, joint pain or abdominal pain. Usually, if you have a onetime sensitivity, the Salmonella typhi with relapses has the same sensitivity profile. You can always use third generation Cephalosporin again in this situation since your mom was sensitive to it in the first place. Again, as I mentioned earlier, we should look for a source where the Salmonella is anchoring and is emerging again and again as the full blown infection. In case she does not have the sensitivity, we would have to treat this as fever of unknown original and look into different possibilities what can cause her repetitive fevers.