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Which treatment is best for me at 27 after three miscarriages?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am a 27-year-old female with a weight of 121 pounds and a height of 5 feet 2 inches. I have had three recurrent miscarriages.

What treatment is best, and what tests are required in this situation?

Thank you.

Hello,

Welcome to icliniq.com.

I read your query and understand your concern.

Treatment will be dependent on the cause of recurrent abortions. In about 30 to 50 percent of cases, the cause is undetectable. I would suggest that you do the following investigations.

  • USG (ultrasound) pelvis scan.

  • Thyroid profile.

  • APLA (Antiphospholipid antibodies) test.

  • TORCH (toxoplasmosis, rubella, cytomegalovirus, herpes simplex, and HIV) test.

  • CBC (complete blood count).

  • Urine routine microscopy test.

I would also suggest you start taking Progesterone and Aspirin whenever pregnancy occurs to prevent miscarriage. Consult your specialist doctor, talk to them, and then take the medications.

Please answer a few questions so I can answer you better.

  • Do you have a family history of congenital anomalies?
  • Did you and your spouse have a consanguineous marriage?

Please revert.

Thank you.

Patient's Query

Hello doctor,

Thank you for your reply.

My marriage is not consanguineous. I underwent a medical abortion for the first time, and the second time I had a surgical abortion. After the second abortion, we conducted a Chromosomal Microarray Analysis, and the report came back normal.

That is why we planned for the next pregnancy. However, during the third pregnancy, a blighted ovum occurred (heparin injections were given after missed periods). Now, my doctor has suggested that my partner and I undergo a couple's karyotyping test.

The report for the couple's karyotyping showed a pericentric inversion in one of the chromosomes 9, involving the region p12q13. Could this be the reason?

  • Which tests should be done for recurrent abortions?

  • Which treatment is best in this situation?

  • Which option is considered the most effective: using donor sperm with IVF or using the husband's sperm and wife's egg with IVF?

  • Given my husband's karyotype report indicating chromosomal abnormalities, which fertility treatment is preferable: IUI or IVF?

  • In IVF, what are the key factors to consider when choosing the best donor sperm and the associated costs of the IVF procedure?

Kindly give detailed answers to the above questions.

Thank you.

Hello,

Welcome back to icliniq.com.

Based on the karyotype study, the presence of a pericentric inversion in chromosome 9 could potentially contribute to the abortions, but it cannot be confirmed as the sole reason. As I have already mentioned, I would suggest you undergo additional investigations such as APLA, TORCH test, blood glucose levels, serum progesterone, USG scan, and, if there is a family history of thromboembolism, BT, and CT (bleeding time and clotting time). These are essential investigations in cases of recurrent abortions.

Donor sperm is typically used when there are abnormalities in the partner's sperm. IVF (in-vitro fertilization) procedures, on the other hand, have a success rate of around 50 percent, which may require multiple attempts. If you are able to conceive naturally, there is no need to pursue IVF (although there might be a higher risk of abortion compared to natural conception).

If considering IVF, it is important to note that it is expensive. Therefore, it is recommended that you undergo a comprehensive work-up before deciding to proceed with IVF.

After an abortion, it is advisable to wait at least three months before attempting pregnancy again, as the body requires time to recover. Additionally, I would suggest you start taking Folic acid tablets at least three months prior to planning a pregnancy.

I hope this helps you.

Thank you.

Patient's Query

Hello doctor,

Thank you for your detailed reply.

We have done all the above mentioned tests like thyroid, blood sugar, and other normal blood test. All the reports were normal.

Thank you.

Hello,

Welcome back to icliniq.com.

I have gone through the reports (attachments removed to protect the patient’s identity). The tests I had mentioned, including APLA, TORCH, progesterone, and others, are missing in the report.

Kindly revert with it.

Thank you.

Medically reviewed byiCliniq medical review team

Published At October 7, 2023
Reviewed AtAugust 1, 2025

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