HomeAnswersObstetrics and Gynecologymissed periodIs it safe to take Mifepristone plus Misoprostol pills one week after a missed period?

I had intercourse 25 days back, and I missed my periods. Should I take Mifepristone pills?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Preetha. J

Published At November 6, 2020
Reviewed AtSeptember 15, 2023

Patient's Query

Hi doctor,

I am a female who is 5.3 feet tall and weighs about 127 lbs. I had intercourse 25 days back. My menstrual period should come 12 days before, but I missed my periods. I did not take any medication, and the hCG urine test was negative. Is it safe to take Mifepristone plus Misoprostol pills one week after a missed period even though HCG urine tests are negative?

Hi,

Welcome to icliniq.com.

Thanks for reaching out. Mifepristone and Misoprostol are hormonal medicines used for termination of pregnancy. If your urine pregnancy test is negative, you should not be taking these medicines. As these are hormonal medicines, there are a lot of unwanted side effects of these medicines. My recommendation is not to take this medicine now on the background of just a missed period and urine pregnancy test negative. Ideally, if your periods do not come next week, you should repeat the urine pregnancy test. I hope this helps you with your query. Feel free to reach out with any further questions.

Patient's Query

Hello doctor,

Thanks for your reply.

What if the urine pregnancy test keeps on showing negative even though I am pregnant?

Hi,

Welcome back to icliniq.com.

It is very unlikely that a urine pregnancy test will be negative if you are pregnant. In that case, you can do a blood beta hCG (human chorionic gonadotropin) test, which will be very confirmatory.

Patient's Query

Thank you, doctor, for your reply.

I have done a blood beta HCG test. I got a result of <2.0 mIU/mL. What does it mean?

Hi,

Welcome back to icliniq.com.

I went through your query again. Beta HCG levels less than five means the person is not pregnant. In your case, it is two, which means you are not pregnant. So you do not need to take Mifepristone and Misoprostol. There is no pregnancy at this time, so do not stress. If you have not got your periods yet, you should take tablet Meprate or Medroxyprogesterone acetate 10 one tablet twice a day for seven days. Bleeding will occur within five to six days of stopping the pill. I hope this answers your query. Feel free to reach out with any further questions.

Patient's Query

Hello doctor,

Thanks for your reply.

I have not got my periods yet. It has been 16 days of missed period. Never in my life, I had experienced such missed periods. Do I need to take any more tests? Or the medicines that you have prescribed for me are sufficient? Are there any side-effects of taking the above-prescribed medicine?

Hello,

Welcome back to icliniq.com.

There could be some hormonal disturbances, which could be the reason behind these delayed periods.

Other reasons could be,

1. Stress.

2. A recent lifestyle change.

3. Weight loss.

4. Thyroid disorders.

5. PCOS (polycystic ovarian syndrome).

So you could do some investigations to know the cause behind this,

  1. Thyroid function test.
  2. Complete blood count.
  3. Fasting insulin levels.
  4. Random blood sugar.
  5. Serum prolactin.
  6. Ultrasound pelvis.

The medicines I have prescribed are sufficient but have side effects like bloating, nausea, and breast tenderness. It will have very mild side effects.

Patient's Query

Hello doctor,

I had done the tests complete blood count test, thyroid function test, prolactin test recommended by you. And prolactin levels are at 49.2 ng/ml and all others showed normal levels. I still have not got periods. Kindly help.

Thank you.

Hello,

Welcome back to icliniq.com,

I can understand your concern.

It would be hyperprolactinemia which is mostly causing menstrual disturbances. I advise you to get a pelvis ultrasound and would like to know if you have started Meperate (Medroxyprogesterone acetate) medication.

I hope this information will help you.

Thank you.

Patient's Query

Hello doctor,

I have not taken a Meperate tablet and I did not get the ultrasound done. Can I be made sure that I am not pregnant? Kindly suggest.

Thank you.

Hello,

Welcome back to iclinq.com.

I can understand your concern.

I have reviewed the reports (attachments have been removed to protect the patient's identity) and as blood beta HCG (Beta-Human Chorionic Gonadotropins) and urine beta HCG are negative, it indicates that you are not pregnant. I advise you to repeat blood beta HCG or do an ultrasound as blood beta HCG levels get doubled every two days in pregnancy.

I hope this information will help you.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

I have taken Azithromycin and Paracetamol one day before the test and would like to know if these medicines affect the prolactin test results. Also I had typhoid last year and also missed my period once before it got regular. Does it also affect my missed period this year? I do not find any discharge from my nipples. How do I find out that 'prolactin-producing cells inside the pituitary gland' have formed tumor?? Is it cancerous and deadly?? Do I need to be worried??

Hello,

Welcome back to icliniq.com.

I can understand your concern.

Azithromycin and paracetamol do not affect the prolactin levels. Also, there will not be any effect of the last year's typhoid infection on this period of delay. The prolactin levels are only mildly elevated. Some women with borderline elevated prolactin levels can have infertility, menstrual irregularities, nipple discharge, and also breast tenderness. There will not be a chance of prolactin-secreting tumors in your case, as women with prolactin-secreting tumors usually have high prolactin levels and symptoms like visual disturbances, loss of interest in sex, and infertility. I advise you to follow the below-mentioned instructions.

  1. Continue taking Cabergoline tablet as advised and it will help in decreasing the prolactin levels.
  2. Get an MRI (magnetic resonance imaging) scan to exclude pituitary tumors if in case the prolactin levels do not come down.
  3. Stop taking any anti-reflux medicines containing Domperidone (usually combined with pantoprazole), as prolactin levels increase.

Kindly consult a specialist, talk to them, and take the medications with their consent.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

I have bought tablets of Meprate10mg and Cabergoline 0.5 mg and I donot know how to take them. Kindly suggest.

Thank you.

Hello,

Glad to have you back at icliniq.com.

I can understand your concern.

The tablets Meperate (Medroxyprogesterone acetate) and Cabergoline act through different mechanisms. I advise you to follow the below-mentioned instructions.

  1. Finish Meperate dosage first and start Cabergoline from next week.
  2. Take medication at the same time every day for best results.

I hope this information will help you.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

I am an unmarried woman and am concerned if these medicines pose any unwanted fertility issues later on after marriage. Can you explain to me the dosage of both medicines? Kindly suggest.

Thank you.

Hello,

Welcome back to icliniq.com.

I can understand your concern.

Increased prolactin levels interfere with the release of eggs, and so can affect fertility. But when prolactin levels normalize after treatment with Cabergoline, fertility improves a lot. Regarding the Meperate tablet, it does not affect fertility as you will be taking it for a short period for withdrawal bleeding. I advise you to follow the below-mentioned instructions.

  1. Take 0.5mg of Cabergoline tablet twice a week at the same time after food (to prevent nausea) for eight weeks or two months.
  2. Repeat the test for prolactin levels after two months.
  3. In most cases, prolactin levels come down after eight weeks of treatment with Cabergoline. Also
  4. Take 10mg Meperate (Medroxyprogesterone acetate) twice a day for seven days, then stop. It will take around six to eight days for withdrawal bleeding to occur.
  5. Kindly consult a specialist, talk to them, and take the medications with their consent.

I hope this information will help you.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

Does taking 10mg of Meprate twice a day mean consuming 10mg once in the morning and another 10mg in the evening after food? Kindly clarify.

Thank you.

Hello,

Welcome back to icliniq.com.

I can understand your concern.

Meperate can be taken before food or after food. Side effects like bloating, mood swings, and mild breast tenderness, and will subside on their own.

I hope this information will help you.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

It has been seven days since I started taking a tablet of Meprate and my periods have started. I have noticed a foul smell and am concerned if it is normal. Kindly help.

Thank you.

Hello,

Glad to have you back at icliniq.com.

Foul smelling of menstrual bleeding can be normal for a day. But if the foul smell continues for more than two days or if there is crampy lower abdomen pain, I advise you to follow the below-mentioned instructions.

  1. Do a high vaginal swab culture and sensitivity test to see if there is any infection.
  2. Stop taking the Meperate tablet.

I hope this information will help you.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

Since my period has started, should I continue taking Cabergoline tablet? Kindly suggest.

Thank you.

Hello,

Welcome back to icliniq.com.

I can understand your concern.

I advise you to continue taking Cabergoline tablets for eight weeks to normalize the prolactin levels.

I hope this information will help you.

Thank you.

Patient's Query

Hello doctor,

Thank you for the reply,

After consuming Cabergoline tablets, I am having trouble with constipation. Can you suggest me some laxative? Should I continue with the medication? Kindly suggest.

Thank you.

Hello,

Welcome back to icliniq.com.

I can understand your concern.

Cabergoline causes some gastrointestinal side effects like nausea, vomiting, constipation, or diarrhea in some people. I advise you to follow the below-mentioned instructions.

  1. Take Movicol (Polyethylene glycol) sachets, two at night time, or Senna (Cassia senna), twoteaspoons at bedtime with a glass of water. Consume at least 2.5 liters of water every day.
  2. Do not stop the tablet Cabergoline and continue it for eight weeks.
  3. Kindly consult a specialist, talk to them, and take the medications with their consent.

I hope this information will help you.

Thank you.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Priyadarshini Tripathy
Dr. Priyadarshini Tripathy

Obstetrics and Gynecology

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