Q. I want to know whether the general functions of mitochondria are checked?

Answered by
Dr. Sudheer Ambekar
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Apr 27, 2016 and last reviewed on: Feb 10, 2020

Hello doctor,

My brother has done a muscular biopsy. I want to know whether the general functions of the mitochondria have been checked and verified in this muscular biopsy. In the hospital, they have checked the muscular biopsy and they are as follows: ATPases (9.4, 4.63, 4.35), menadione, succinate dehydrogenase, DNPH, phosphorylase, adenylate deaminase and cytochrome oxidase.

Dr. Sudheer Ambekar

Neuro Surgery Neurology
#

Hello,

Welcome to icliniq.com.

  • The diagnosis of mitochondrial disease was based on the presence of characteristic ragged red fibers (RRF) in more than 2 % of muscle fibers in the muscle biopsy (attachment removed to protect patient identity).
  • RRFs are not pathognomonic of mitochondrial diseases, but can also be seen in other conditions like dystrophies and dermatomyositis.
  • The usual stains used in the diagnosis of mitochondrial disorders are:
  1. Gomori trichrome stain.
  2. Succinate dehydrogenase stain.
  3. Cytochrome oxidase.
  4. ATPase (4.3, 4.6, 9.4).
  • I agree that with the list of enzymes provided mitochondrial pathology has been ruled out.

For further information consult a family physician online --> https://www.icliniq.com/ask-a-doctor-online/family-physician


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