Q. Why is my neutrophil number dropping?

Answered by
Dr. Prakash H. Muddegowda
and medically reviewed by Dr. Hemalatha
This is a premium question & answer published on Jul 10, 2016 and last reviewed on: Aug 19, 2020

Hi doctor,

I recently had my blood tests done for unexplained bruising, mouth sores, muscle pain and headaches. The neutrophil number came back as low of 1.2. I looked back at my past laboratory results and the neutrophil number has been dropping as follows. First it was 3.4, then 3.2, 2.9, 2.7, 2.1 and now 1.2. Could this be a sign of something more serious? I take Enbrel for psoriatic arthritis and also, my immune system is low.



Welcome to

Based on your query, my opinion is as follows:

  • If the immune system were being affected, then I would like to look at the whole picture of WBC count (white blood cell) and decide.
  • Psoriatic arthritis is a chronic disease and in chronic diseases, the lymphocytes increase. When the counts are being done, the count is usually done for 100 cells.
  • If lymphocytes increase, the neutrophils will reduce and if the neutrophils increase, the lymphocytes will reduce. As you have psoriatic arthritis, other WBC would have increased and hence neutrophil is appearing low.
  • Unexplained bruising is probably related to platelet count. If the platelet count is normal, then it could be a complication of psoriatic arthritis on blood vessels.
  • The muscle pain and headaches could be due to psoriatic arthritis. The mouth sores could be due to side effect of Etanercept.
  • If the immune system were to be affected, both lymphocytes and neutrophils would be reduced or the whole WBC count and if there was bone marrow suppression, all cells including RBC and platelets would be affected.
  • At present, as the lymphocytes are increased, the neutrophils appear to be reduced. The symptoms are more of a side effect of psoriatic arthritis and its treatment. Nothing serious related to neutrophils. Not to be worried.

For further information consult a hematologist online -->

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
I am getting radiating right hip pain. Is this due to psoriatic arthritis?

Is this a case of psoriatic arthritis ... Lastly, this is not normally a presentation of psoriatic arthritis ...   Read full

How long should I take Humira?

I have been suffering from ankylosing spondylitis for at least 15 years ...   Read full

Which foods are beneficial in arthritis?

.. seen your reports (attachment removed to protect patient identity). Your RA factor is positive. So, for confirming rheumatoid arthritis, anti-CCP investigation can be done. Local part X-ray also needs to be done. Spinach, beet juice, and green l...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

Monkeypox Virus - Symptoms, Diagnosis, Treatment, Complications, and Prevention
Monkeypox is a zoonotic viral disease. This virus got its name as it was first noticed in laboratory monkeys in the late...  Read more»
Tomato Fever - Causes, Symptoms, Diagnosis, Treatment, and Prevention
Tomato fever is an unidentified and fast-spreading type of viral infection seen in young children. Scroll down to know m...  Read more»
Histrionic Personality Disorder - Causes, Signs, Symptoms, Diagnosis and Treatment
Histrionic personality disorder causes variations in the thinking ability of a person. Read this article to know more.  Read more»

Ask your health query to a doctor online?

Ask a Hematologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.