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HomeAnswersSexologysex driveHow can I increase my sex drive while on antidepressants?

Do antidepressants cause low sex drive?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Ashok Kumar

Medically reviewed by

iCliniq medical review team

Published At October 14, 2015
Reviewed AtDecember 26, 2023

Patient's Query

Hi doctor,

I have no sex drive whatsoever and cannot obtain an orgasm. Please help.

Answered by Dr. Ashok Kumar


Welcome to icliniq.com.

I read your query with due interest and understand your concerns. Low sex drive is a common symptom of a variety of medical and psychiatric disorders. Before I speculate anything about it I need you to answer a few questions in detail.

  1. Mention the duration of the problem? Whether both the problems are of the same duration or different?
  2. When did you attain menopause?
  3. What is your current relationship status and how long are you in it?
  4. How is the relationship, is there any conflict between both of you?
  5. Do you have any psychological issues like depression, anxiety or even simple stress?
  6. Do you take any medications or substance of abuse including alcohol? If yes, please mention the dosage or frequency and amount of it?
  7. Have you undergone any surgery particularly on genitals or breast?
  8. Do you experience any pain during intercourse?
  9. Do you exercise regularly? What about your weight and anthropometric parameters?
  10. Any other thing you want to share?

Once you answer the above questions it will be helpful to suggest the appropriate measures.

Patient's Query

Hi doctor,

My problem has been going on for about four years. Currently, I am not in a relationship. I am post-menopausal and I am not taking any hormonal replacement. I am suffering fromanxiety and depression and take numerous medications such as Prozac, Klonopin, Trazodone, and Zyprexa.

Answered by Dr. Ashok Kumar


Welcome back to icliniq.com.

Although your answers were not detailed, it has given me three potential causes for low sex drive and orgasm problem.

1. The first of them is Prozac (Fluoxetine). It is well known that Prozac decreases the sex drive and causes a problem with orgasm in both men and women.

There are two options to treat this cause.

First, if you are having a good response to Prozac then add on therapy with Bupropion or Mirtazapine. Since these are prescription medications, you need to talk to your doctor about this. In my clinical experience, I got better results with a low dose of Bupropion like 150 mg per day.

The second option is to replace Prozac with some other antidepressants. I generally prefer Mirtazapine or SNRI (serotonin-norepinephrine reuptake inhibitors) when such a situation arises but there are a variety of antidepressants which can work for you. This option is more suitable if you are still struggling with depression and stress issues and Prozac is not giving sufficient results.

2. The second possible cause is depression and anxiety itself. As described above the change in medication should help you if there is an inadequate response regarding depression and anxiety.

3. Thirdly the postmenopausal period is a prominent cause of low sex drive. This seems more probable cause as you have the problem for last four years (I guess you had menopause around the same time). For this, there is an option of hormone replacement therapy (HRT). As we know there are risks associated with systemic HRT, you can use estrogen as vaginal cream or suppository which helps in low sex drive and helps in the problem.

In addition to the above medical measures, there are other lifestyle changes which will help you to a great extent such as,

  1. Regular aerobic and stretching exercise of 30-45 minutes. This lifts your mood and increases sex drive.
  2. Avoidance of junk foods and high-calorie diets.
  3. Avoidance of substance of abuse if any.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Ashok Kumar
Dr. Ashok Kumar


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