ADVERTISEMENT

Q. Does taking tablet Sulfasalazine impair my Sjogren's syndrome affected wife's Type 1 interferon production?

Answered by
Dr. Sugreev Singh
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on May 22, 2022

Hi doctor,

My wife has had Sjogren's syndrome and related rheumatoid arthritis for about ten years. She has been experiencing a flare for five months now, which has migrated from her knees to her heel and hands. She is nearing 70. She is currently on tablet Sulfasalazine 500 mg, two in the morning and two at night. Occasionally she takes tablet Ibuprofen 800 mg for pain. Studies indicate that tablet Sulfasalazine impairs Type 1 interferon production by plasmacytoid dendritic cells, which can inhibit the immune system from battling the COVID-19 virus. As such, tablet Sulfasalazine has increased the risk of a severe outcome from COVID by 360 percent, or a 3.6 odds ratio. In an international journal, patients with a COVID infection were evaluated, in which 390 (10.5 percent) died. Contrastingly, initial studies by a leading medical center reported rheumatic disease patients were not at increased risk.

So I wonder what my wife's risk is, mainly since she is on tablet Sulfasalazine. Would it be better for her to switch to tablet Methotrexate, as that has been shown to have a lower odds ratio of increased risk?

Please advise me, doctor.

Thank you.

ADVERTISEMENT
#

Hi,

Welcome to icliniq.com.

I can understand your concern.

It differs from person to person. Some people have a higher risk, while some do not. But since she has Sjogren's, I would suggest you continue with the same medicine and take precautions for COVID. Even if she stops the medication, there are chances that she may get other infections. So the best way is to continue with the same and take proper precautions. Every person has a different body and immunity. So do not worry about anything.

Thanks and regards.


Was this answer helpful?

 | 

Same symptoms doesn’t mean you have the same problem. Consult a doctor now!



Related Questions:
Is there any difference between Sjogren's syndrome and SLE?

Because of these, the patient has a gritty feeling in the eyes most of the day and difficulty in chewing and deglutition of food ...   Read full

Are Wysolone, HCQS, Saaz and Shelcal safe during pregnancy?

.. sulfate), Prednisolone (Wysolone), Shelcal (Calcium carbonate and Vitamin D3) are relatively safe in pregnancy and your doctor will stop Saaz (Sulfasalazine) and if possible, Wysolone too. For more information consult a rheumatologist online --&g...   Read full

I am concerned about Sjogren's syndrome due to dry eyes and mouth. Kindly interpret my blood report.

However, I had reported mild dry mouth and mild dry eyes ... My eye doctor confirmed via tests that I do have mild dry ...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read


Monkeypox Virus - Symptoms, Diagnosis, Treatment, Complications, and Prevention
Monkeypox is a zoonotic viral disease. This virus got its name as it was first noticed in laboratory monkeys in the late...  Read more»
Tomato Fever - Causes, Symptoms, Diagnosis, Treatment, and Prevention
Tomato fever is an unidentified and fast-spreading type of viral infection seen in young children. Scroll down to know m...  Read more»
Histrionic Personality Disorder - Causes, Signs, Symptoms, Diagnosis and Treatment
Histrionic personality disorder causes variations in the thinking ability of a person. Read this article to know more.  Read more»

Ask your health query to a doctor online?

Ask a Rheumatologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.