I have autoantibodies in my blood and some related specific proteins. What could they indicate?

Q. What does the presence of autoantibodies in the blood indicate?

Answered by
Dr. Ashaq Hussain Parrey
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Oct 27, 2022 and last reviewed on: Jul 21, 2023

Hello doctor,

I have autoantibodies in my blood and some related specific proteins. I still do not have serious symptoms. I can send my results.



Welcome to icliniq.com.

I went through your post and investigations. There are a few significant results in the autoimmune profile. Your ANA (antinuclear antibody), dsDNA (double-stranded deoxyribonucleic acid), and anti-Ro are positive, which is suggestive of SLE (systemic lupus erythematosus). However, to make the diagnosis of any connective tissue disease, we need to have symptoms, signs, and investigations. I would suggest updating your symptoms; whatever you have will at least help.

Thank you.

Hello doctor,

I had a lip biopsy three years ago, and the result was negative for Sjogren's disease. I had dry eyes and still have them. Four months ago, I closed the tear ducts, and the situation became better. I sometimes suffer from pain in the joints of the fingers, but it disappears without drug interaction. Three months ago, I had COVID-19 without serious symptoms. More than a week ago, I had muscle pain in my legs, but it disappeared after I exercised. I smoke an average of 10 cigarettes per day and have stopped menstruating for the last six months. I do not complain of any other diseases, but I had a hernia operation about six years ago without serious pain and without drug consumption. I have taken three doses of the COVID-19 vaccine.



Welcome back to icliniq.com.

The symptoms are suggestive of Sjogren's syndrome, but dsDNA is generally negative in Sjogren's; however, an undifferentiated connective tissue disease with secondary Sjogren's is a possibility. What were Schirmer's test and sialometry results? A biopsy is helpful, but only 70 % have positive results for multiple reasons and depending on the stage of the disease. Therefore, my diagnosis is Sjogren's syndrome, likely due to undifferentiated connective tissue disease.

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