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How does the medication Sorafenib work in treating liver cancer?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At April 10, 2024
Reviewed AtApril 10, 2024

Patient's Query

Hello doctor,

My relative was recently diagnosed with liver cancer, and the doctor suggested taking a medication called Sorafenib. Can you provide some information on how the medication Sorafenib works in treating liver cancer? I am trying to understand its potential benefits and any side effects that might come with it. Additionally, are there other treatment options or complementary approaches that can be considered alongside Sorafenib? I just want to gather as much information as possible to support my relative through this challenging time. Kindly help.

Thank you.

Hello,

Welcome to icliniq.com.

I can understand your concern.

Liver cancer is a very bad cancer with a poor prognosis except if the tumor can be resected completely at a very early stage. For advanced liver cancers (HCC- Hepatocellular carcinoma), immunotherapy using Nivolumab or Pembrolizumab is a better option than Sorafenib.

Sorafenib belongs to a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells. Sorafenib suppresses tumor cell proliferation and angiogenesis (formation of new blood vessels) and promotes tumor cell apoptosis (programmed cell death). It was approved by the FDA (Food and Drug Administration) for the treatment of advanced liver cancer and as a unique target drug for advanced hepatocellular carcinoma (HCC) in 2007.

The common side effects of Sorafenib include:

  1. Bleeding gums.

  2. Blistering, peeling, redness, or swelling of the palms of the hands or bottom of the feet.

  3. Bloating of the abdomen or stomach.

  4. Blood in the urine or stools.

  5. Clay-colored stools.

  6. Coughing up blood.

  7. Difficulty breathing or swallowing.

Most of the side effects are manageable under close monitoring.

I hope I have answered all your queries.

Do get back in case of any further queries.

Thank you.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Arshad Hussain Shah
Dr. Arshad Hussain Shah

Medical oncology

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