HomeAnswersEndocrinologythyroid nodulesHow can we determine if the enlargement of a thyroid nodule in a 62-year-old male is indicative of malignancy?

Does an increase in thyroid nodule size indicate malignancy?

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Published At October 18, 2023
Reviewed AtOctober 18, 2023

Patient's Query

Hello doctor,

I am a 62-year-old male with a history of IgA nephropathy for the past 13 years. I am currently being treated with Cardace 10 mg, Stamlo 5 mg, Rosuvas 10 mg, and fish oil capsules for this condition.

Additionally, I have multiple thyroid nodules, which are being monitored without any specific treatment. I also have a benign prostate (38 cc, Grade 2) for which I am taking Urimax 0.4 mg medication. My blood pressure is around 130/80, and I maintain a daily exercise routine of 45 minutes.

I have attached the recent blood and urine test results taken this month. I also underwent a thyroid scan today, and I have attached both the recent and previous years' thyroid scan reports.

According to the recent thyroid scan report, one of the nodules has increased in size from 0.88 cm to 1.09 cm within a year. The scan report has classified the grade as TIRAD IV, which, based on my reading, suggests potential malignancy. I am seeking your opinion on the possible malignancy of these thyroid nodules based on the scan reports.

I would appreciate your guidance on what my next steps should be.

Thank you.

Hi,

Welcome to icliniq.com.

Thank you for writing and I understand your concern.

The nodule is hypoechoic, but there is no mention of other features like echogenic deposits, height>width, or irregular borders, which are essential to categorize it as TIRADS IV.

However, I recommend obtaining a reevaluation by the radiologist to update the TIRADS (Thyroid Imaging Reporting and Data Systems) score, especially since they mentioned a benign or adenomatous etiology. If the images are available, I can also review them for further assessment.

Regarding the size increase, there is a slight difference between the previous measurement from last year (0.88) and the recent one (1.09), possibly due to the placement of calipers during measurement. Nevertheless, it is essential to consider the size increase, and if it continues to grow, a fine-needle aspiration cytology (FNAC) should be performed.

As of now, my opinion remains that it is still the same nodule (low risk for malignancy) with probable slight growth. I suggest following up with a repeat ultrasound in 6 to 12 months to monitor any further changes.

Feel free to reach out for further queries or clarifications.

Thank you.

Patient's Query

Hi doctor.

Thank you so much for your prompt reply which gave me some reassurance. I was quite tense when I read the scan report.

The report does mention that there is no calcification and there is a thin halo around the nodules. Does this point to a benign nodule?

I have attached the scanned image for your review and comments.

Thanks once again for your promptness.

Hello,

Welcome back to icliniq.com.

Yes, it is mentioned in the report that there are no calcifications, which is a positive finding. Regarding the halo, it does not hold significant clinical value in this context.

Upon reviewing the images (attachements removed to protect the patient’s identity), it is evident that the dominant right nodule is very hypoechoic, has defined borders, and is located very close to the thyroid capsule. Considering these features, the ATA (American Thyroid Association) risk score classifies it as an intermediate-risk nodule, and the recommendation is now to proceed with fine-needle aspiration cytology (FNAC) since the size is more than 1 cm in its largest dimension.

I have revised my opinion based on the personal review of the images provided, with the understanding that real-time viewing was not possible. The decision for FNAC is made based on both the ATA risk score and individual judgment considering its proximity to the thyroid capsule. While TIRADS IV nodules can be followed without FNAC if they are less than 1 cm in size, in this case, the size of the nodule exceeds 1 cm, warranting further evaluation through FNAC.

I hope this information helps you.

Feel free to ask further queries.

Thank you.

Patient's Query

Hello doctor,

Thank you for your response.

I went back to the lab and asked about the TIRAD 4 rating. They admitted an error in the rating while printing the report and changed the rating from TIRAD 4 to TIRAD 3.

Does the classification as TIRAD 3 change your opinion regarding immediate FNAC?

Hi,

Welcome back to icliniq.com.

Yes, since malignancy is highly probable in TIRADS 3. I would suggest you get a FNAC done.

Thank you.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Thiyagarajan. T
Dr. Thiyagarajan. T

Diabetology

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