Will Prednisone inhalation show changes in thyroid levels?

Q. Does inhalation of Prednisone cause alteration in thyroid hormones?

Answered by
Dr. Mohammed Abdul Nasir
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Dec 09, 2020 and last reviewed on: Jun 08, 2023

I went to the hospital at the beginning of last month for an allergic reaction. I was given inhaled Epinephrine and 2 shots of Prednisone. 2 days later I went back to the ER for the same thing and was given another shot of Prednisone and put on a 5 day treatment of Prednisone, 80mg a day. It turns out that I was allergic to a newly purchased hamster. I could not tolerate the Prednisone. It felt like my heart was going to beat right out of my chest. My allergist and my primary doctor advised me to stop the Prednisone, and I was sent to a cardiologist. The cardiologist is not too worried about my heart after my EKG and examination, but I have further testing this week. My question is, should I be worried about my adrenals? It has been about 3 weeks since the Prednisone, and my symptoms seem largely hormonal. I have no appetite, I can not tolerate normal portions without an upset stomach. I have had moments of abnormally high (for me) heart rate while standing (120+)and sitting (90s), and my blood pressure is sometimes higher than what is normal for me (normal is usually 110/68, it has gotten to 125/75). I feel like my blood sugars might be low, which isn't subsiding after eating what I can. I'm a 35 yr old female with hypothyroidism and obesity. So, what should I do here?

Ask for a referral to an endo, or do something else? Any ideas or thoughts would be greatly appreciated.



Welcome to iCliniq.com.

I have read your problem. The thing about corticosteroids is that they mimic some of the hormones that are produced in the body. There is something known as HPA axis which is basically hypothalamic-pituitary-adrenal axis. If corticosteroids are given externally for a long time then our body stops producing the required steroids. So if the steroids are stopped abruptly then we might have a problem with the HPA. Symptoms of low corticosteroids in the body are different from what you are describing. Since you are given corticosteroids for about 5 days and you took them for how many days is not actually clear from your question I would say that it even if you have abruptly stopped taking the steroids It wouldn't affect your body steroid production because they were not given for a long time.

You also say that you are hypothyroid. Are you taking medicine for the same? Alteration in your thyroid hormone levels in the body could explain some of the symptoms that you are describing. Let me know if you have done thyroid profile anytime in the past 1 to 2 months. Your palpitation can also be explained by your thyroid levels. Do let me know the answer some of the questions which I have asked above. Let me know if you have any further questions.

I would be happy to help

Investigations to be done:

thyroid profile

Probable diagnosis:

HP access separation or hyperthyroidism

Treatment plan:

shall decide after the questions are answered

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