My wife is 28 years old, and her weight is 49 kg. She is on Thyronorm 75 for past one year. We did some blood tests a year back as per our gynecologist's advice in view of positive ANA two years back which came normal in the same year. According to that, her IgG for antiphospholipid was normal, and IgM was positive. Also, IgG and IgM for toxoplasmosis were positive. Our doctor started tablet Rovamycin Forte and Ecosprin 75. She took Rovamycin Forte for two months.
Eight months back we again checked for toxoplasmosis which was found negative, i.e., IgG and IgM for toxoplasmosis were negative. Hence, the doctor stopped Rovamycin but continued Ecosprin 75. Two months later, my wife became pregnant, and her LMP was at the end of the same month. Two months later, the doctor again advised for antiphospholipid and toxoplasmosis. IgG and IgM for antiphospholipid were negative, but IgG and IgM for toxoplasmosis were dramatically high. Hence, the doctor started Rovamycin Forte again. Now, we are taking Rovamycin Forte for past six months again. Please guide me on the below queries:
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Yes, to rule out acute infection or re-infection there is a role of IgM avidity testing and once the toxoplasmosis IgM is negative and IgG titers are high, then IgG titer is repeated every four weeks.The rising titers are suggestive of active infection, and amniocentesis is done to detect congenital toxoplasmosis infection in placenta and baby.
If an active infection is there, then to prevent the transmission of infection to the baby, Rovamycin (Spiramycin) in a dose of 1 to 2 gm daily for three weeks and then one week off for three to four months is given. It is the infection which affects the baby's growth and not the drug itself so much. Yes, the answer to the question is amniocentesis to detect PCR (polymerase chain reaction) in the placenta and baby.
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