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Is uterine fibroid with cysts a side effect of Depo shot?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

Last month, I was given a Depo shot to stop intermenstrual bleeding that started six months after Provera tablets did not work. Unable to do a pap smear because of the bleeding. Transvaginal ultrasound revealed a tiny (0.3 x 0.5 inch) uterine fibroid, three hemorrhagic cysts, and a heterogeneous endometrial cavity.

Earlier, I passed clots that looked like blood mixed with chicken meat. I am terrified. Is this a side effect, or do I need to go to the ER?

Please help.

Thank you.
Answered by Dr. Sree Gouri. S. R

Education:

MBBS

Professional Bio:

Dr. Sree Gouri is a compassionate Obstetrician and Gynecologist dedicated to supporting women’s health at every stage of life. She combines her clinical expertise with a keen eye for detail and thorough radiological insight to provide accurate diagnoses and effective care. Known for her attentive listening, strong communication, and analytical approach, Dr. Sree Gouri works closely with patients to help them make informed decisions about their health. She practices at Susruta Polyclinic in Tirupati, offering personalized, patient-centered care focused on long-term wellness and overall well-being.

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Hi,

Welcome to icliniq.com.

Thanks for the query. I can understand your concern.

According to your description, the possibilities are a hormonal imbalance leading to thickened endometrium and menstrual irregularities. If there is any possibility of pregnancy, please go for a urine pregnancy test once to rule out a missed abortion. If the bleeding with passage of possible endometrial tissue persists better to go for dilatation and curettage once.

With this, the possible cause of your problem can be identified, and sometimes curettage by removing abnormal endometriotic tissue may cure the problem and may regularize the next menstrual cycles. Antifibrinolytic drugs like Tranexamic acid can help in controlling abnormal bleeding.

I hope this helps.

Kindly revert in case of further queries.

Thank you.

Medically reviewed by Dr. Vinodhini J.
Published At March 26, 2020
Reviewed At April 17, 2026

Education:

MBBS

Professional Bio:

Dr. Sree Gouri is a compassionate Obstetrician and Gynecologist dedicated to supporting women’s health at every stage of life. She combines her clinical expertise with a keen eye for detail and thorough radiological insight to provide accurate diagnoses and effective care. Known for her attentive listening, strong communication, and analytical approach, Dr. Sree Gouri works closely with patients to help them make informed decisions about their health. She practices at Susruta Polyclinic in Tirupati, offering personalized, patient-centered care focused on long-term wellness and overall well-being.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Education:

BDS

Professional Bio:

Dr. Vinodhini J. is a Dental Surgeon with extensive years of clinical experience. She specializes in the diagnosis, prevention, and treatment of dental and oral health issues, including restorative, surgical, and cosmetic procedures. With a patient-centered approach, she focuses on maintaining oral health, alleviating discomfort, and enhancing smiles. Her expertise ensures comprehensive care tailored to each patient’s dental needs and overall wellbeing.

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Dr. Sree Gouri. S. R

Obstetrics and Gynecology

Education:

MBBS

Professional Bio:

Dr. Sree Gouri is a compassionate Obstetrician and Gynecologist dedicated to supporting women’s health at every stage of life. She combines her clinical expertise with a keen eye for detail and thorough radiological insight to provide accurate diagnoses and effective care. Known for her attentive listening, strong communication, and analytical approach, Dr. Sree Gouri works closely with patients to help them make informed decisions about their health. She practices at Susruta Polyclinic in Tirupati, offering personalized, patient-centered care focused on long-term wellness and overall well-being.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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