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Is uterine fibroid with cysts a side effect of Depo shot?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

Last month, I was given a Depo shot to stop intermenstrual bleeding that started six months after Provera tablets did not work. Unable to do a pap smear because of the bleeding. Transvaginal ultrasound revealed a tiny (0.3 x 0.5 inch) uterine fibroid, three hemorrhagic cysts, and a heterogeneous endometrial cavity.

Earlier, I passed clots that looked like blood mixed with chicken meat. I am terrified. Is this a side effect, or do I need to go to the ER?

Please help.

Thank you.

Hi,

Welcome to icliniq.com.

Thanks for the query. I can understand your concern.

According to your description, the possibilities are a hormonal imbalance leading to thickened endometrium and menstrual irregularities. If there is any possibility of pregnancy, please go for a urine pregnancy test once to rule out a missed abortion. If the bleeding with passage of possible endometrial tissue persists better to go for dilatation and curettage once.

With this, the possible cause of your problem can be identified, and sometimes curettage by removing abnormal endometriotic tissue may cure the problem and may regularize the next menstrual cycles. Antifibrinolytic drugs like Tranexamic acid can help in controlling abnormal bleeding.

I hope this helps.

Kindly revert in case of further queries.

Thank you.

Medically reviewed byDr. Vinodhini J.

Published At March 26, 2020
Reviewed AtApril 17, 2026

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