I have suddenly lost adipose tissue, and I suffer from anemia along with EBV infection. Can blood donation in such a situation cause sudden weight loss?

Q. Will a patient with anemia and EBV infection have sudden weight loss if he tries to donate blood?

Answered by
Dr. Kanani Darshan Jayantilal
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Apr 25, 2023 and last reviewed on: May 24, 2023

Hello doctor,

On my SPEP, there is a slightly raised total protein, 83 (66 to 81), and immunoglobulins show raised IGA level of 4.74. Electrophoresis shows beta globulins are a bit elevated at 11.5 (6 to 9.4), and gamma globulins at 13.8 (8 to 13.5). I have suddenly lost adipose tissue. Can blood donation with anemia and EBV infection cause sudden weight loss? I did not know I had any of those, and I was a regular blood donor. And now I have sudden iron deficiency anemia, high cholesterol and triglycerides, peripheral neuropathy in my left arm, soft vertically ridged nails, and a scalloped tongue.

I have done the following laboratory tests: CBC a few times, colonoscopy, gastroscopy, MSCT abdomen and thorax, abdomen ultrasound, and echocardiogram.



Welcome to icliniq.com.

I thoroughly read your query and understand your concern.

Based on the information you provided, there are a few possible explanations for your symptoms and test results. The elevated total protein and gamma globulin levels, along with the slightly elevated beta globulins, suggest that there may be an underlying inflammatory or immune-related process occurring in your body. The elevated IgA (immunoglobulin A) level also supports this possibility. In general, your AG ratio (albumin and globulin ratio) is normal, so it is due to inflammation only which can be explained by IDA (iron deficiency anemia). Iron deficiency anemia can cause weight loss and some infections such as EBV (Epstein-Barr virus), but donating blood will not cause IDA as such. You should look for the color of your stool, if it is black then a small amount of blood loss can cause IDA, or else it is due to nutritional deficiency. The presence of high cholesterol and triglycerides, peripheral neuropathy, soft vertically ridged nails, and a scalloped tongue could suggest nutritional deficiencies or autoimmune disorders. Peripheral neuropathy at your age is not common unless you have a deficiency of vitamin B12, copper, or vitamin E. It is good that you have already undergone a range of tests, but it may be helpful if you took a few additional tests, such as a comprehensive metabolic panel and a vitamin and mineral panel, which may help identify any underlying nutritional deficiencies.

I hope this clears your query.

Feel free to contact me for further queries.

Kind regards.

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