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The Basics of Blood Types

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Blood types are based on the presence or absence of specific antigens, chemicals that, if foreign to the body, can cause an immune reaction.

Medically reviewed by

Dr. Abdul Aziz Khan

Published At April 15, 2024
Reviewed AtApril 15, 2024

What Is Blood?

Blood is a unique kind of bodily fluid. Red blood cells, white blood cells, platelets, and plasma comprise its four primary constituent parts. Blood serves a variety of purposes, such as:

  • Delivering nutrition and oxygen to the tissues and lungs.

  • Coagulating blood to stop excessive bleeding.

  • Containing antibodies and cells that combat infection.

  • Transporting waste materials to the liver and kidneys cleans and filters the blood.

  • Controlling one's body temperature.

Whole blood, roughly half blood cells, and half plasma, flows via veins, arteries, and capillaries. It makes up seven to eight percent of the total body weight. The average size of a man's blood is approximately 12 pints, whereas the average size of a woman's blood is approximately 9 pints.

Components of blood:

  • Plasma.

  • Red blood cells or erythrocytes.

  • White blood cells or leukocytes.

  • Platelets or thrombocytes.

What Are the Types of Blood?

Healthcare professionals can ascertain whether the blood type is compatible or incompatible with another person's blood through a blood type classification system. The four primary blood types are O, B, AB, and A. Blood bank professionals can identify the blood type based on the presence of antigen A or B in the red blood cells. They search for a protein known as the Rh factor as well. If one contains this protein, the blood type is classified as positive (+) and, if not, as negative (-).

  1. Group A: Red blood cells only contain the A antigen, while plasma has the B antibody.

  2. Group B: Red blood cells carry the B antigen exclusively, while plasma has the A antibody.

  3. Group AB: Red blood cells have both A and B antigens (but no A or B antibody in the plasma).

  4. Group O: Red blood cells lack A and B antigens, whereas plasma contains A and B antibodies.

The eight most frequent blood types are formed by the presence or absence of a protein known as the Rh factor, which is in addition to the A and B antigens. The types are as follows.

1. A Positive (A+):

  • It is one of the most prevalent blood types in the country, accounting for 35.7 percent of all transfusions.

  • Able to receive all A and O types and provide blood products to types A+ and AB+.

  • They are the perfect donor for apheresis platelets, double red blood cells, or whole blood.

2. A Negative (A-):

  • It is among the rarest blood kinds; just 6.3 percent of Americans have type A blood.

  • Able to receive kinds A- and O- and provide blood products to all A and AB types.

  • They are the perfect donor for apheresis platelets, double red blood cells, or whole blood.

3. B Positive (B+):

  • It is among the rarest blood kinds; just 8.5 percent of Americans have type B+ blood.

  • Able to receive all B and O kinds and provide blood products to AB+ and B+ types.

  • They are the perfect donor for apheresis platelets, double red blood cells, or whole blood.

4. B Negative (B-):

  • It is among the rarest blood types; just 1.5 percent of people in the country have type B-.

  • Able to receive kinds O- and B- and provide blood products to all B and AB types.

  • It is the perfect donor for apheresis platelets, double red blood cells, or whole blood.

5. O Positive (O+):

  • It is one of the most prevalent blood types, accounting for 37.4 percent of all transfusions.

  • They can receive and provide blood products to all O and Rh+ types (A+, B+, O+, and AB+).

  • They are the perfect donor of either whole or double red blood cells.

6. O Negative (O-):

  • It is one of the rarest blood types; just 6.6 percent of the population have type O-.

  • Type O blood products are universally available to all donors.

  • They are the perfect donor of either whole or double red blood cells.

7. AB Positive (AB+):

  • It is among the rarest blood kinds; only 3.4 percent of the public have type AB+ blood.

  • They are the universal recipient, allowing blood products of any blood type to be administered.

  • They are the universal plasma donor, which allows their plasma to be received by people of any blood type.

  • It is the perfect donor of plasma or whole blood.

8. AB Negative (AB-):

  • It is the most uncommon blood type; only 0.6 percent of people worldwide have type AB-.

  • They are the universal plasma donor, making AB plasma available to everybody.

  • They are the perfect donor of plasma, red blood cells, or whole blood.

How Can the Blood Transfusion Be Done Based on Blood Type?

For a transfusion to be safe, blood types need to match in extremely precise ways. Transfusions of the appropriate blood can be the difference between life and death. For additional information on matching blood types for transfusions, utilize the interactive graphic below. Patients who test negative for Rh are also given Rh-negative blood; those who test positive for Rh may receive Rh-positive or Rh-negative blood. For plasma, the regulations are the opposite.

1. Donor O: Anyone can receive red blood cells from Group O. This donor is universal. So the recipient from them will be:

  • Group A.

  • Group B.

  • Group O.

  • Group AB.

2. Donor A: The recipients from them are:

  • Group A.

  • Group AB.

3. Donor B: The recipients from them will be:

  • Group B.

  • Group AB.

4. Donor AB: Group AB can receive from all other ABs and donate to others. Therefore, the recipient will be

  • Group AB.

How Can the Blood Group Be Predicted?

One group comes from the mother, and the other from the father. Here is the list of factors by which one can predict the blood group.

  • O + O = O.

  • O + A = O or A.

  • O + B = O or B.

  • O + AB = A or B.

  • A + A = O or A.

  • A + B = O, A, B, or AB.

  • A + AB = A, B or AB.

  • B + B = O or B.

  • B + AB = A, B or AB.

  • AB + AB = A, B or AB.

A Universal Blood Donor: What Is It?

A blood type of O negative is identified as a universal donor. It is possible to transfuse any blood type using O-negative blood. As type O negative blood represents the universal blood type required for emergency transfusions and immune-deficient babies, it is often in limited supply and high demand by hospitals.

Although type O (positive or negative) is present in about 45 percent of Caucasians, it is more common in African-Americans (51 percent), Hispanics (57 percent), and other groups. Consequently, minority and diverse communities are essential to supplying the ongoing demand for blood.

Both O-positive and O-negative blood types are in great demand. Although O-negatives comprise just seven percent of the population, there is a greater need for O-negative blood because it is most frequently used in emergencies. O+ is highly required because it comprises most blood types (37 percent of the population). The blood type of the universal red cell donor is Type O negative. The blood type of the universal plasma donor is AB. See the plasma donation facts for additional information.

Conclusion

The presence or lack of specific antigens, chemicals that, if foreign to the body, might cause an immune response, determines the blood type. Safe blood transfusions depend on meticulous blood typing and cross-matching since some antigens can cause a patient's immune system to attack the transfused blood. ABO is the most significant blood group system, while there are other blood group systems employed as well. The presence or lack of two antigens (A and B) on the surface of red blood cells determines the ABO type. The presence or lack of two antigens, A and B, on the surface of red blood cells, results in one of four primary blood types (A, B, AB, and O).

Dr. Abdul Aziz Khan
Dr. Abdul Aziz Khan

Medical oncology

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