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Cognitive Enhancers: Types, Safety, and Risks of Smart Drugs

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Cognitive enhancers are believed to improve mental performance through physical, biochemical, and behavioral activities.

Medically reviewed by

Dr. Abhishek Juneja

Published At October 17, 2023
Reviewed AtOctober 17, 2023

Introduction:

Cognitive enhancers are a fascinating and famous topic in neuroscience and cognitive science. These substances, which range from prescription drugs to natural supplements, are believed to enhance cognitive function in various ways, such as improving memory, attention, and creativity. With the growing demands of modern life, many people are turning to cognitive enhancers to boost their mental performance and stay ahead of the curve. However these substances can offer potential benefits, but they also come with risks and limitations that must be considered carefully.

What Are Cognitive Enhancers?

Cognitive enhancers or smart drugs are substances designed to improve mental performance, including memory, focus, and attention. These substances have gained popularity over the years, and more and more people are looking for ways to boost their cognitive abilities and stay competitive.

Some cognitive enhancers are prescription medicines, and others are available over-the-counter or online. With their ability to enhance cognitive function and improve productivity, cognitive enhancers have become a hot topic in neuroscience and beyond.

How Do Cognitive Enhancers Work?

Cognitive enhancers include prescription drugs such as Adderall, Ritalin, and Modafinil and over-the-counter supplements like caffeine, ginkgo biloba, and omega-3 fatty acids. The exact mechanism of action of these substances varies depending on the type of enhancers used. However, they are believed to affect the levels of certain neurotransmitters in the brain, which are chemical messengers that allow neurons to communicate with each other.

What Are the Types of Cognitive Enhancers?

Cognitive enhancers include eugeroics, ADHD medications, and Nootropic supplements.

1. Eugeroics: These are a group of drugs that stimulate alertness and wakefulness. They are called 'wakefulness-promoting agents' and are used to treat conditions such as narcolepsy, obstructive sleep apnea, and shift work sleep disorder. This group includes Modafinil, Armodafinil, and Adrafinil. Due to their high selectivity action on CNS (central nervous system), eugeroics potentially have a low addictive property compared to other stimulants. Side effects of eugeroics include:

  • Anxiety.

  • Headache.

  • Increased alertness and focus.

  • Reduced fatigue.

  • Dizziness.

  • Nervousness.

  • Pins and needles.

  • Chest pains.

  • Sleeplessness.

2. ADHD (Attention-Deficit Hyperactivity Disorder) Medications: ADHD medications, particularly stimulants such as Methylphenidate and Amphetamine, have been used by some individuals as cognitive enhancers. These medications are thought to improve attention, focus, and mental processing speed, which can enhance cognitive performance. The effects of these medications can vary depending on the individual and their specific brain chemistry and cognitive abilities. Misuse or abuse of these medications leads to serious health consequences. Side effects include:

  • High body temperature.

  • Paranoia (persistent feeling of threat) or hostility.

  • Cardiovascular system failure.

  • Euphoria (a great sense of joy) or heightened sense of well-being.

  • Reduced fatigue, appetite, and drowsiness.

  • Increased sex drive.

  • Feelings of cleverness, great competence, and power.

  • Increased activity, alertness, and talkativeness.

  • Dry mouth, nausea, headaches, and dilated pupils.

Long-term side effects include:

  • Stomach ulcers and malnutrition.

  • Skin disorders, flushed or pale skin, and vitamin deficiency.

  • Dizziness and difficulty breathing.

  • Mental health and behavioral problems.

  • Irregular or rapid heartbeat, potential inflammation of heart valves, and high blood pressure.

  • Loss of coordination and physical collapse.

  • Convulsions and coma.

  • Repetitive physical actions.

  • Unusual weakness or tiredness.

3. Nootropic Supplements: Nootropic supplements are supplements that are claimed to improve cognitive function, such as memory, focus, and attention. These supplements are often marketed as "smart drugs" or "brain boosters" and are commonly taken by students, professionals, and other individuals seeking to improve their mental performance. Some of the most popular nootropic supplements include:

  • Caffeine: A stimulant that can improve focus and alertness.

  • L-Theanine: An amino acid that is commonly found in tea and can improve focus, relaxation, and mood.

  • Bacopa Monnieri: An herb used in ayurvedic medicine to improve memory and cognitive function.

  • Ginkgo Biloba: An herb that is thought to improve memory and concentration.

What Are the Risks and Safety Concerns of Cognitive Enhancers?

The risks of cognitive enhancers or smart drugs include:

  • Side Effects: Smart drugs may have side effects like any other medication. The side effects can range from mild, such as headaches or nausea, to more severe side effects, such as seizures or heart palpitations.

  • Addiction: Some intelligent drugs can be addictive. This means that people who use them may develop a dependence on the drug and have difficulty stopping its use.

  • Abuse: Smart drugs are often used by people without medical need, such as college students trying to improve their academic performance. This can lead to abuse, which can have serious consequences, including addiction and overdose.

  • Interactions With Other Drugs: Smart drugs can interact with other medications, such as antidepressants or blood thinners, which can cause adverse reactions.

  • Unknown Long-Term Effects: Many smart drugs have not been extensively studied for long-term use, meaning their long-term effects on the brain and body are largely unknown.

  • Quality and Safety of Supplements: Over-the-counter cognitive enhancers like herbal supplements, are not strictly regulated like prescription medications. Hence, their purity, potency, and safety are not guaranteed. Some supplements may contain ingredients or contaminants which can be harmful.

  • Legality: The use of certain cognitive enhancers may be illegal without a valid prescription or may violate anti-doping regulations in some competitive settings which is unfair and leads to serious problems.

  • Individual Variability: The effects of cognitive enhancers vary from person to person. What works effectively for one individual may not have the same effect for another or it may have adverse effects.

What Are the Benefits of Cognitive Enhancers?

Some of the potential benefits of smart drugs:

  • Improved Cognitive Function: Smart drugs improve cognitive function, including memory, attention, and decision-making abilities. This can be especially helpful for people experiencing cognitive decline due to aging or neurological conditions.

  • Increased Productivity: Smart drugs help people be more productive by improving focus, reducing distractions, and increasing motivation.

  • Enhanced Creativity: Smart drugs also enhance creativity and cognitive flexibility by improving neural connections and increasing the brain's ability to make new associations.

  • Better Academic Performance: Some students believe smart drugs can help them perform better academically by improving memory, focus, and information retention.

  • Improved Athletic Performance: Some smart drugs, such as caffeine and creatine, may improve athletic performance by increasing energy, endurance, and focus.

  • Increased Energy and Wakefulness: Some cognitive enhancers promote wakefulness and alertness, making them potentially useful for individuals who need to stay awake and focused for prolonged periods.

Conclusion:

Cognitive enhancers, smart drugs, can improve cognitive performance, memory, and concentration. However, they also come with potential risks such as addiction, adverse side effects, and long-term effects on the brain. It is necessary to consider the risks and benefits carefully and discuss any concerns with a healthcare professional. Cognitive enhancers should not be a substitute for healthy lifestyle habits.

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Dr. Abhishek Juneja
Dr. Abhishek Juneja

Neurology

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