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Mood Stabilizers: Types, Side Effects, and Complications

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Mood stabilizers are effective medications to treat bipolar disorders, depression, and anxiety, with a range of side effects. Read the article to learn more.

Medically reviewed byDr. Kaushal Bhavsar

Published At November 7, 2023
Reviewed AtMay 6, 2025

Introduction

In bipolar disorder, your mood can shift between feeling depressed (low or sad) and mania (high or excited). Mood stabilizers help keep these ups and downs under control. Mood stabilizers are drugs to treat mood swings in bipolar disorders.

They do not work immediately, though. It can take a few weeks to get the full effect. That is why doctors might prescribe mood stabilizers with other medications, like antipsychotics. These combinations will help with manic episodes in the beginning.

Mood stabilizers can have side effects and complications. Hence, you must be aware of and note any changes occurring in your body and visit your doctor immediately.

What Are Mood Stabilizers?

Like its name, mood stabilizers are medicines that help keep your mood stable. They control certain brain chemicals like serotonin, dopamine, and norepinephrine. These are the things that help balance your mood. If you have bipolar disorder, depression, or anxiety, they can help stop these big mood changes so you do not feel high one moment and low the next.

The main goal? To make those mood swings less severe and less frequent.

Feeling depressed with bipolar disorder can be tricky because it looks a lot like regular depression. Mood stabilizer medications are used mainly to treat bipolar disorder, but they might not work for all symptoms. They do not cause addiction, but if you have been taking them for a long time, your body might get used to them. When you stop suddenly, you might experience withdrawal effects.

Common Uses of Mood Stabilizers:

Mood stabilizers are FDA-approved drugs to treat bipolar disorder. They can also be used for:

  • Major depressive disorder (MDD).

  • Schizophrenia.

  • Borderline personality disorder.

  • Mood swings.

  • Post-traumatic stress disorder (PTSD)

How Do Mood Stabilizers Make You Feel?

Mood stabilizers can make you feel balanced. Though not instantly, it gives big relief in the long run. Here’s how it works! Mood stabilizers work by selecting certain receptors in your brain that control the balance of brain chemicals. By adjusting the way these brain chemicals work, mood stabilizer drugs can help ease symptoms of bipolar disorder and other mental disorders. It can take a few weeks before you start to feel the medication's effects.

What Are the Types of Mood Stabilizers?

Mood stabilizers are available in various types. Some of the common ones are Lithium, Valproic acid, Carbamazepine, and Lamotrigine. Each medicine has its unique benefits, ways of working, and side effects. Let us learn about them:

  1. Lithium is one of the oldest and most well-known mood stabilizers. It is often used to control manic episodes and keep mood swings in check over the long run. While scientists are still uncovering how exactly it works, one popular theory is that it helps calm overactive nerve signals by lowering the inositol levels in the brain. It is effective and does come with some side effects, such as:

  • Shaky hands (tremors).

  • Weight gain.

  • Feeling tired or sluggish.

  • Thyroid problems.

  • Frequent urination and thirst.

  • Kidney issues.

  1. Valproic acid is another powerful mood stabilizer that is used for bipolar disorder, seizures, and even migraine prevention. It works by boosting GABA (gamma-aminobutyric acid), a brain chemical that slows down overactive nerve activity, helping to reduce mood swings and seizure episodes. Common side effects include:

  • Upset stomach.

  • Weight gain.

  • Hair thinning.

  • Shaky hands.

  • Easy bruising.

  • Liver problems.

  • Confusion or extreme tiredness.

  • Not safe in pregnancy as it can harm the unborn baby.

  1. Carbamazepine is often used to stabilize moods in bipolar disorder, treat seizures, and manage trigeminal neuralgia, a painful condition that affects the face. It works by blocking overactive nerve signals, helping to prevent mood swings and nerve pain. It can cause side effects such as:

  • Nausea.

  • Vomiting.

  • Diarrhea.

  • Rash and itchy skin.

  • Drowsiness or a sleepy feeling.

  • Dizziness or lightheadedness.

  • Blurred or double vision.

  • Headaches.

  • Weakness and confusion are caused by lower sodium levels, which are caused by Carbamazepine, which makes you feel weak, tired, and confused.

  1. Lamotrigine is especially helpful for preventing future mood episodes in bipolar disorder and also works as an anticonvulsant for seizures. It reduces the release of glutamate, a brain chemical that excites nerve cells, while boosting GABA, which has a calming effect, creating a better balance in brain activity. While many people tolerate it well, some can experience side effects like:

  • Nausea.

  • Stomach discomfort.

  • Tremors or shaky hands.

  • Severe skin rash.

How to Manage the Side Effects of Mood Stabilizers?

Tips for Managing Side Effects:

  • For sun sensitivity, wear sunscreen and protective clothing.

  • Take the medication with food or milk to avoid stomach issues.

  • If your medication makes you drowsy, then take it at bedtime.

  • For weight gain, regular exercise and a healthy diet low in sugar and fat and high in fiber, like fruits, vegetables, and whole grains, can help you keep your weight in check.

  • For Lithium-related side effects, check your blood regularly to avoid complications and toxicity.

Conclusion:

Mood stabilizers can help keep bipolar disorder under control, but they are not without side effects. These can include weight gain, stomach issues, kidney and thyroid problems, trouble with thinking and memory, and even liver problems. It is important to monitor your symptoms and keep in touch with your doctor. They can adjust your medication if needed to help you feel better while avoiding complications. By understanding both the uses and side effects of mood stabilizers, you can now find the right balance to manage your symptoms and improve your mental health.

Key Takeaway/ Note From iCliniq:

Here at iCliniq, the doctors know the importance of mood stabilizers, their uses, side effects, and complications. Mood stabilizers can work by controlling the brain's chemicals and calming the mind. They act on stabilizing the mood in bipolar disorder.

If you are on mood stabilizers and experiencing some kind of discomfort, or have doubts about dosage and its uses, or side effects. At iCliniq, the doctors can give you professional advice and plan your treatment accordingly.

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