Melancholic Depression - An Overview

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Are you feeling intensely sad or hopeless? You might be experiencing melancholic depression, which affects about 25 to 30% of those with depression. Read to know more about it.

Medically reviewed by Dr. Vipul Chelabhai Prajapati
Published At April 26, 2024
Reviewed At March 13, 2025

Education:

Bachelors in dental surgery

Professional Bio:

Dr. Salwa Mohamed is a Dental Surgeon with clinical experience of 2 years. She graduated from Dayananda Sagar College of Dental Sciences in 2018. She is a passionate clinician with keen interest and expertise in oral medicine and radiology.

This doctor is not available for online consultations on the platform anymore.

Education:

MBBS

Professional Bio:

Dr. Vipul Chelabhai Prajapati is a Psychiatrist with 15 years of clinical experience. He completed his MBBS from B. J Medical College in 2008. He then completed his Diploma in Psychiatric Medicine (D.P.M.) from the University of Gujarat in 2012. He patiently listens to the patient's concerns and works towards the patient's well-being. He is currently working in Gujarat.

This doctor is not available for online consultations on the platform anymore.

Table of Contents

What Is Melancholic Depression?

Melancholic depression is a type of major depression. The word "melancholia" comes from Greek and means deep sadness. It mainly affects the brain. People with this depression feel very sad and lose interest in things they once enjoyed. It is different from other types of depression. Because of this, it may need different treatments.

What Are the Symptoms of Melancholic Depression?

Do you have symptoms of major depression for more than two weeks? You may have Melancholia. Melancholia symptoms appear as follows:

  • Loss of pleasure or interest in almost all activities.

  • Deep sadness, hopelessness, or despair.

  • Loss of appetite.

  • Weight loss.

  • Excessive sleepiness.

  • Slowing down of movements and speech.

  • Feelings of worthlessness, guilt, or self-blame.

  • Difficulty concentrating, making decisions, or remembering things.

  • Recurrent thoughts of death or suicide.

  • Physical symptoms, such as fatigue, aches, or headaches.

  • Lack of response to positive events or situations.

If your symptoms are similar to depression but are severe and persistent, then you are experiencing melancholic symptoms. Melancholia causes most people to slow down. Their movements, thoughts, and speech can all be extremely slow. Agitation and restlessness are less common symptoms of melancholia.

Melancholy vs. Depression: Depression is a feeling of sadness. Melancholy is a passing feeling of sadness that is temporary.

What Are the Causes of Melancholic Depression?

The exact cause of depression is not known. Some of the possible causes are -

  • Neurotransmitters are chemicals that send signals to the brain. If they are unbalanced, brain function is affected.

  • Having a family history of depression or mental illness can increase the risk of melancholic depression.

  • Hormonal changes can also cause depression.

What Are the Risk Factors of Melancholic Depression?

You are at risk of developing melancholic depression if you have any of the following risk factors.

  • Genetics: A history of any form of mental health disorder increases the risk of melancholia.

  • Age: Melancholic depression is more common in older adults than younger ones.

  • Gender: Some studies suggest that women are more likely to develop melancholia than men.

  • Medical Conditions: Individuals with chronic conditions such as heart disease, cancer, or chronic pain may have an increased risk of developing melancholia.

  • Medications: Certain medications, such as corticosteroids, beta-blockers, and some hormonal medications, may increase the risk of developing depression.

How to Diagnose Melancholic Depression?

Melancholic depression is not considered a separate illness. If you experience depressive symptoms along with melancholy, it is diagnosed as a major depressive disorder with melancholic features. An individual is said to have a melancholic personality when more than three of the following symptoms are observed:

  • Loss of interest in activities.

  • Non-reactivity to circumstances.

  • Inability to do normal physical or mental activities.

  • Memory loss and lack of concentration.

  • Weight loss.

  • Loss of appetite.

How to Treat Melancholic Depression?

Melancholic depression is treated using medications like antidepressants and psychotherapies. If the condition fails to improve with these, then electroconvulsive therapy is used.

1. Electroconvulsive Therapy:

  • This therapy is used when the symptoms fail to subside with medication or psychotherapy.

  • It is a procedure done under general anesthesia.

  • During this therapy, electrical signals are sent to the brain.

  • These signals will induce chemical changes in the brain.

  • It will help to relieve the symptoms of melancholic depression.

2. Medications: Doctors frequently use tricyclic antidepressants for managing the symptoms of melancholic depression. However, other antidepressants and medications can also be prescribed by them. Tricyclic antidepressants include -

  • Amitriptyline.

  • Amoxapine.

  • Desipramine.

  • Doxepin.

  • Imipramine.

  • Nortriptyline.

Consult with your doctor to choose the best medicine for you.

3. Psychotherapy or Talk Therapy:

  • Psychotherapy, or talk therapy, involves talking with a physician, psychiatrist, or other mental health professional. You can feel free to discuss about your feelings, beliefs, and actions.

  • This therapy will help you to understand how to overcome negative thoughts. It also impacts how to change your behavior healthily.

  • However, the symptoms of melancholic depression are not well managed by psychotherapy.

  • Psychotherapy includes -

    • Cognitive Behavioral Therapy - This helps replace negative thoughts and actions with healthy beliefs and behavior.

    • Dialectical Behavioral Therapy - It is a type of CBT that helps to control emotions.

    • Interpersonal Therapy - It assists you in understanding underlying interpersonal difficulties that are troubling, such as unresolved sorrow, changes in responsibilities, and disputes with others.

4. Alternative Methods: Alternative methods include -

  • Yoga.

  • Meditation.

  • Regular exercise.

  • Following a well-balanced diet.

  • Sufficient sleep.

These, along with other forms of therapies, will help manage the symptoms. Incorporating these small changes will make a major difference in your life.

What Are the Complications of Melancholic Depression?

If not treated, melancholic depression will result in various complications which include both physical and mental illnesses.

Some of them are as follows -

  • Loss of weight.

  • Anxiety.

  • Heart diseases.

  • Panic attacks.

  • Workplace difficulties.

  • Relationship issues.

  • Uncontrolled alcohol drinking.

  • Low energy to perform physical activities.

Conclusion:

Melancholic depression is a severe form of depression. Melancholic psychology affects the individual's standard of living, While the exact causes of melancholic depression are unknown, a combination of genetic, environmental, and biological factors, such as imbalances in brain chemicals, stressful life events, medical conditions, and medications, play a crucial role in causing the condition.

Therefore, it is important to recognize the melancholic features and get it diagnosed and treated promptly. Treatment options include medications, psychotherapy, and electroconvulsive therapy. Melancholy feelings rarely respond to placebos, psychotherapies, or social interventions compared to non-melancholic depression. Yet, it is important to discuss with a physician to determine the treatment plan according to your needs and improve one's overall quality of life.

Keynote From iCliniq:

Melancholic depression is a serious mental health disorder. If you experience any symptoms related to this condition, consult a psychiatrist and get it treated immediately. You will be able to handle your symptoms if you stick to the treatment plan and follow a healthy lifestyle

Frequently Asked Questions

Do melancholics get angry easily?

Melancholics are usually quiet and composed, but they have strong emotions. They often hide their emotions and opt to stay calm and composed manner in all extreme situations like enjoyment or rage. But if they are forced extremely hard, they will lose their temperament. Melancholic patients respond better to electroconvulsive therapy (ECT) and certain medications, such as tricyclic antidepressants (TCA) and monoamine oxidase inhibitors (MAOIs) than to selective serotonin reuptake inhibitors (SSRIs) that are given in patients suffering from MDD.

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