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Role of Lipoic Acid in Visual Acuity

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Visual acuity is the measure of the sharpness of one’s eyesight. This article focuses on the role of lipoic acid in maintaining visual acuity.

Written by

Dr. Sanchana. N

Medically reviewed by

Dr. Gopal R. Damani

Published At January 24, 2024
Reviewed AtJanuary 24, 2024

Introduction:

An indicator of vision clarity or sharpness is called visual acuity. Usually, an eye chart is used to assess it, and the results are given as a fraction. The Snellen notation, which bears the name of the Dutch ophthalmologist who created the Snellen eye chart, is the accepted unit of measurement for visual acuity.

During regular eye tests, visual acuity is tested, which is an important part of maintaining good eye health. Visual acuity can be impacted by conditions like astigmatism, hyperopia, and nearsightedness (myopia). By correcting for refractive errors in the eye, corrective lenses—such as glasses or contact lenses—are frequently prescribed to help improve visual acuity. Furthermore, disorders of the eyes, like macular degeneration or cataracts, can affect vision and may call for medical attention.

What Is a Snellen Fraction?

When calculating a Snellen fraction, the denominator is the smallest line of letters or symbols that the test subject can accurately read, and the numerator is the test distance, which is typically 20 feet in the US and 6 meters in other countries. When someone has 20/20 vision, for instance, it indicates that they can see at 20 feet what someone with normal vision can see at 20 feet. A person with 20/40 vision has a lower level of visual acuity because it indicates that they can see at 20 feet what a person with normal vision can see at 40 feet.

How Does Lipoic Acid Work?

Lipoic acid, or alpha-lipoic acid (ALA) or thioctic acid, is a naturally occurring substance that the body makes in trace amounts. Because it is fat- and water-soluble, it can function in a variety of cellular settings. ALA is regarded as an antioxidant and is involved in several biological functions. An outline of its mode of action is provided below:

  • Antioxidant Properties: Lipoic acid's ability to act as an antioxidant is one of its main advantages. Free radicals are extremely reactive molecules that have the potential to damage cells. It aids in their neutralization. Lipoic acid can scavenge these free radicals and thereby shield cells from oxidative stress.

  • Regeneration of Other Antioxidants: Vitamins C and E are among the other antioxidants that lipoic acid can regenerate. These antioxidants undergo oxidation once they have neutralized free radicals. By aiding in the restoration of their antioxidant qualities, lipoic acid can strengthen the body's defense mechanisms against free radicals.

  • Chelation: Lipoic acid can chelate, or bind, to certain metals, including iron and copper. This characteristic aids in keeping these metals from taking part in processes that produce free radicals.

  • Support for the Mitochondria: Lipoic acid plays a role in energy metabolism, specifically in the mitochondria, which are the organelles inside cells that produce energy. By functioning as a cofactor for important enzymes involved in mitochondrial function, it helps to produce adenosine triphosphate (ATP), which is the main source of energy for cells.

  • Anti-inflammatory Effects: Studies on lipoic acid have demonstrated its ability to reduce inflammation. It might alter inflammatory pathways, which would aid in lessening inflammation in the joints, eyes, and nerves, among other tissues.

  • Neuroprotection: The possible neuroprotective effects of lipoic acid have been investigated. It may be important for conditions affecting the nervous system, which includes the eyes, as it may help shield nerve cells from harm and maintain their functionality.

What May Be the Dietary Sources of Lipoic Acid?

Alpha-lipoic acid (ALA) is naturally present in small amounts in certain foods. While the body can synthesize ALA, getting it from dietary sources can contribute to overall intake. Here are some dietary sources of lipoic acid:

  • Red Meat: Particularly, organ meats such as liver and kidney, as well as muscle meats, contain some amounts of lipoic acid.

  • Spinach: Leafy greens, including spinach, contain ALA. However, the levels are relatively low compared to some other sources.

  • Broccoli: Broccoli and other cruciferous vegetables may contain small amounts of lipoic acid.

  • Tomatoes: Tomatoes and tomato-based products, such as tomato paste or sauce, contain lipoic acid.

  • Brussels Sprouts: Brussels sprouts are another cruciferous vegetable that contains some ALA.

  • Peas: Green peas are a source of lipoic acid.

  • Potatoes: Potatoes, particularly in their skin, contain small amounts of lipoic acid.

Who Is Susceptible to Take Lipoic Acid?

Alpha-lipoic acid (ALA) supplements or dietary intake from food sources may be something to think about for people with certain health issues, concerns, or lifestyles that may benefit from its potential benefits. The following demographics may be more likely to think about ALA intake in their diets:

  • People With Diabetes: According to some research, ALA may be helpful for people with diabetes, especially when it comes to glycemic control and diabetic neuropathy. Individuals with diabetes should talk to their healthcare provider about the possible advantages and disadvantages of taking ALA supplements.

  • Individuals With Diabetic Retinopathy: Diabetic retinopathy is an ocular complication of diabetes. The potential protective effects of ALA against inflammation and oxidative stress linked to diabetic retinopathy have been investigated.

  • People With Neurological Conditions: Because of its neuroprotective qualities, ALA has been studied with people with a variety of neurological conditions. Its application in diseases like multiple sclerosis and Alzheimer's disease has been studied.

  • People Looking for Antioxidant Support: Since ALA is an antioxidant, those who want to bolster their defenses against free radical damage might want to think about consuming it in food or taking supplements. Free radicals are countered by antioxidants, which also lessen oxidative stress in the body.

  • Individuals With Age-Related Eye Conditions: Oxidative stress and inflammation play a part in certain age-related eye conditions, such as macular degeneration. In these situations, the antioxidant qualities of ALA might help to maintain eye health.

  • People With Cardiovascular Concerns: The potential cardiovascular benefits of ALA have been studied. Studies have looked into how it affects vascular function and lipid metabolism.

  • Individuals Who Suffer From Metabolic Syndrome: This group of illnesses includes elevated blood pressure, elevated blood sugar, excess visceral fat, and abnormally high cholesterol. Because of its possible effects on metabolism and as an antioxidant, ALA has been studied with metabolic syndrome.

Conclusion:

The role of lipoic acid in visual acuity is not fully established, but its antioxidant and neuroprotective properties suggest potential benefits for eye health. Limited evidence suggests improvements in visual function, especially in conditions like diabetic retinopathy. However, more research is needed for definitive conclusions. Consultation with a healthcare professional is advised before considering lipoic acid supplementation for eye health.

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Dr. Gopal R. Damani
Dr. Gopal R. Damani

Ophthalmology (Eye Care)

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