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Pulmonary Hypertension and Right Heart Failure: Decoding the Attributes

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Pulmonary hypertension is an increase in pressure in the pulmonary arteries. Read the article to know more about it.

Medically reviewed by

Dr. Muhammad Zohaib Siddiq

Published At March 12, 2024
Reviewed AtMarch 12, 2024

What Is Pulmonary Hypertension?

Pulmonary hypertension is a more general form of diagnosis than a debilitating condition. Pulmonary hypertension (PH) refers to increased blood pressure in the pulmonary arteries. The pulmonary art arteries are the arteries related to the lungs involved in transferring deoxygenated (oxygen-poor) blood from the heart to the lungs.

Pulmonary hypertension is of several types, manifesting according to its underlying cause. Some rare types include pulmonary hypertension, which results from blood clots and occurs in the arteries. On the contrary, pulmonary hypertension from underlying heart and lung problems is quite common.

The average estimation of the prevalence of pulmonary hypertension is about 50 to 70 million people around the world. This accounts for one in 100 people living with pulmonary hypertension. Older adults are more likely to have pulmonary hypertension.

What Are the Types of Pulmonary Hypertension?

Pulmonary hypertension comprises five distinct types based on the underlying cause.

  • Pulmonary hypertension is due to pulmonary arterial hypertension, which affects the pulmonary arteries, resulting in deficient blood flow and increased pressure.

  • Pulmonary hypertension results from left-sided heart disease. The malfunctioning on the left side of the heart will eventually affect the right side of the heart and the total pulmonary circuit.

  • Pulmonary hypertension is due to hypoxia or lung disease. Lung problems could impede the arteries in the lungs, raising the pressure.

  • Pulmonary hypertension is due to blood clots, scars, or blockages in the lungs.

  • Pulmonary hypertension is due to other health disorders, especially blood and metabolic conditions.

What Are the Symptoms Associated With Pulmonary Hypertension?

The initial phase of pulmonary hypertension manifests as shortness of breath during daily functions and exercises. Many people during this phase, many people stay asymptomatic or experience mild symptoms. It gets worse over time, manifesting shortness of breath even at rest.

The other symptoms include the following.

  • Bluish discoloration of the skin and lips.

  • Chest pain and discomfort.

  • Fatigue.

  • Dizziness.

  • Fainting.

  • Pain in the abdomen.

  • Rapid heartbeat.

  • Loss of appetite.

  • Edema (swelling) in the legs and ankles.

What Is the Relation Between Pulmonary Hypertension and Right Heart Failure?

Right heart failure is a pivotal cause of both morbidity and mortality in association with pulmonary hypertension. It has intricate pathophysiology involving adaptive and maladaptive effects in the right ventricle. The elevated pressure in the pulmonary arteries can result in stress on the right side of the heart, especially the right ventricle. Over time, the increased stress and associated overload could cause the right ventricle to weaken and sometimes fail. This condition is generally known as right heart failure.

The right-sided heart failure is a potential complication of pulmonary hypertension because the right aspect of the heart is responsible for pumping the blood from the heart to the lungs. Hence, the right ventricle tends to work hard to overcome the resistance in the pulmonary arteries generated by the increased pulmonary pressure. Therefore, pulmonary hypertension contributes to right heart failure by exerting excessive strain on the right ventricle.

What Contributes to the Connection Between Pulmonary Hypertension and Right Heart Failure?

The connection between pulmonary hypertension and right heart failure involves a range of attributes. They include.

  • Elevated pulmonary pressure demands the right ventricle to work harder to overcome resistance and pump blood into the pulmonary circulation.

  • The chronic stress on the right ventricle could result in right ventricular hypertrophy (thickening of the right heart muscle) when the heart compensates for the elevated workload.

  • The strain in the right ventricle can eventually lead to right ventricular dysfunction.

  • Right ventricle dysfunction can lead to right heart failure over time.

  • Vascular remodeling (structural changes) can occur with pulmonary hypertension, causing the narrowing of the arteries while increasing resistance. This complicates the workload exerted on the right ventricle.

  • Endothelial (lining of the blood vessels) dysfunction has a role in developing pulmonary hypertension and its associated effect on the right side of the heart.

  • Inflammatory processes within the pulmonary vasculature network are attributable to the development of pulmonary hypertension and its impact on the right heart’s function.

How Is Right Heart Failure Diagnosed?

The healthcare professionals perform a physical therapy examination, assessing the vital signs and symptoms. Certain radiographic and blood tests are recommended to evaluate the heart function and determine the risks. They can be chest X-rays, echocardiograms, electrocardiography (EKG), and blood tests measuring natriuretic peptides. Several imaging tests used to validate heart failure and identify the conditions causing the symptoms include computed tomography (CT) scans, magnetic resonance imaging (MRI), stress tests, cardiac catheterization, and exercise stress tests.

What Is the Intervention For Right Side Heart Failure?

Though all causes of right heart failure are not curable, management is always directed towards the cause of the right heart failure. The intervention usually involves a combination of medications, heart devices, and lifestyle adjustments. Medications like diuretics might help mitigate fluid retention, while vasodilators and pulmonary hypertension-allied drugs aim to decrease pulmonary vascular resistance. In severe cases of right heart failure, healthcare professionals consider a surgical intervention called heart transplantation.

Generally, right heart failure is a potentially life-threatening condition that requires conscientious monitoring and care. The prognosis of this correlated cardiovascular challenge could vary depending on the severity of the condition and the individual's response to the intervention. Early recognition and appropriate management of pulmonary hypertension can improve the overall prognosis and outcomes.

Prognosis:

If pulmonary hypertension is identified and managed early, the progression to right heart failure may be slowed, and symptoms alleviated. However, if left untreated or if the underlying cause is challenging to address, right heart failure can lead to significant morbidity and mortality. Prognosis is generally poorer in cases where pulmonary hypertension is advanced or associated with conditions that are difficult to treat. Timely diagnosis, addressing the underlying cause, and appropriate management strategies, which may include medications and lifestyle changes, are critical for improving the prognosis of right heart failure due to pulmonary hypertension.

Conclusion:

Pulmonary hypertension is considered hazardous since it influences and impedes the blood flow through the heart and lungs. The increased blood pressure in the pulmonary arteries narrows them, resulting in malfunctions in pumping oxygen-poor blood from the heart to the lungs. This complication, over time, damages the heart, causing certain problems all over the system. This can even turn out to be fatal if left untreated. Recognizing and managing these conditions is crucial for fostering comprehensive and appropriate care for the people affected by this correlated cardiovascular crisis.

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Dr. Muhammad Zohaib Siddiq
Dr. Muhammad Zohaib Siddiq

Cardiology

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pulmonary hypertensionright heart failure
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