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Infantile Osteomyelitis and Septic Arthritis - A Comparative Review

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Infantile osteomyelitis and septic arthritis are rare but serious bone and joint infections in infants, requiring prompt treatment for optimal outcomes.

Medically reviewed by

Dr. Anuj Gupta

Published At August 10, 2023
Reviewed AtSeptember 12, 2023

Introduction

The most frequent cases of osteomyelitis and septic arthritis are in youngsters. Osteomyelitis is a bone inflammation. A bacterial infection of the bone is commonly referred to as osteomyelitis. Chronic, subacute, or acute osteomyelitis are all possible. Bacteria typically bring on a joint infection known as septic arthritis. Many pathways exist for bacteria to enter the bone and joints. If not properly managed, osteomyelitis and septic arthritis can result in lifelong impairment.

What Is Osteomyelitis?

The most common form of osteomyelitis in children is acute hematogenous osteomyelitis (AHO), with the bacteria typically entering the bone through the bloodstream. Rarely, an infection may spread to the bone through an open wound at the time of an open fracture or after surgery, from an adjacent infected focus, or directly through the bone.

What Is Septic Arthritis?

Several characteristics of acute osteomyelitis and septic arthritis (SA) are the same. The onset is typically abrupt. The joint could become infected in numerous ways. In youngsters, SA typically develops due to bacteria spreading into the joint through blood. SA may be caused by penetrating injuries, particularly to the knee joint. It might also be the result of osteomyelitis spreading across the area.

In babies, a metaphyseal abscess may directly spread through the growth plate, down vascular channels, into the epiphysis, and then into the joint space. Small vessels pass through the proximal growth plate of the femur's metaphysis and epiphysis before the age of 18 months. The vascular pathways disappear around 18 months, at which point the growth plate begins to function as a barrier to the terminal vessels of the metaphysis.

The degradation of the cortex and the spread of pus into the joint space are two additional mechanisms by which a metaphyseal abscess extends into the joint. In some places, the metaphysis is contained within the joint capsule; hence, a joint infection can result from the abscess penetration of the delicate metaphyseal cortex. Although the hip joint is most likely to experience this, it can also happen in the ankle, shoulder, and elbow joints.

It was shown that patients with osteomyelitis had a 33 % incidence of nearby infected joints.

The most significant incident ever recorded in the literature is this one. About 31 % of these nearby joint infections were found in the knee. The age distribution of their patients and the high rate of knee infections indicate that there may be more mechanisms at play in the dissemination of pus from the metaphysis to the joint, in addition to the spread of disease through the growth plate. Most patients with SA who have concurrent osteomyelitis appear with SA symptoms, and the diagnosis of concurrent osteomyelitis is frequently made after radiologic markers of osteomyelitis become apparent.

What Are the Clinical Manifestations of Septic Arthritis?

Septic arthritis displays similar clinical signs to AHO. The youngster has a fever, a sickly appearance, localized pain, and lacks spontaneous movement in the injured joint. Swelling, redness, warmth, and local discomfort appear early in peripheral joints. These typical symptoms usually take a while to appear, and diagnosis is frequently delayed for deep-located joints, particularly the hip joint.

The typical clinical indicators of inflammation, including in peripheral joints, are typically absent in newborns and young children. There is no fever, and the newborn or infant may not seem ill. Accurate diagnosis and identification of the site of infection necessitate a vigilant approach and thorough monitoring. The absence of spontaneous movements in the affected limb is the most frequently seen consistent observation.

The infant will hold the leg flexed, abducted, and externally rotated to lower the intraarticular pressure. Hip joint movement is painful in every way. The late symptoms of this specific joint infection are swelling and redness in the groin. Soft tissue edema, capsular distension, enlargement of the joint cavity, and radiologic indications of nearby osteomyelitis can be visualized on radiographs. Even little joint effusions can be detected with ultrasonography, which can also be used to direct joint suction.

What Are the Differences Between Infantile Osteomyelitis and Septic Arthritis?

Infantile osteomyelitis and septic arthritis are both serious infections that can affect the bones and joints in infants and young children, but they involve different anatomical structures and have some distinct differences. Here are the key differences between infantile osteomyelitis and septic arthritis:

Anatomical Location:

  • Infantile Osteomyelitis: Osteomyelitis is an infection of the bone itself. In infantile osteomyelitis, the infection primarily affects the bone tissue.

  • Septic Arthritis: Septic arthritis, also known as infectious arthritis, is an infection of the joint space. It primarily involves the joint and the synovial fluid within it.

Site of Infection:

  • Infantile Osteomyelitis: The infection occurs within the bone marrow, affecting the bone's inner tissue.

  • Septic Arthritis: The infection occurs within the joint cavity, affecting the synovial membrane and the joint space.

Clinical Presentation:

  • Infantile Osteomyelitis: Symptoms typically include localized bone pain, swelling, redness, and tenderness at the affected bone site. The child may be reluctant to use the affected limb.

  • Septic Arthritis: Symptoms typically include joint pain, swelling, warmth, and limited range of motion in the affected joint. The child may refuse to move the joint due to pain.

Common Sites of Infection:

  • Infantile Osteomyelitis: Common sites of osteomyelitis in infants include the long bones, such as the femur and tibia.

  • Septic Arthritis: Common sites of septic arthritis in infants include the hip and knee joints.

Diagnosis:

  • Infantile Osteomyelitis: Diagnosis often involves imaging studies such as X-rays, MRI, or bone scans to visualize the affected bone. Blood tests may also reveal elevated inflammatory markers.

  • Septic Arthritis: Diagnosis typically involves joint aspiration, where synovial fluid is extracted from the affected joint and analyzed for signs of infection. Blood tests may also show elevated inflammatory markers.

Treatment:

  • Infantile Osteomyelitis: Treatment usually involves intravenous antibiotics to target the bone infection. In some cases, surgical drainage may be necessary to remove pus or infected tissue.

  • Septic Arthritis: Treatment includes prompt drainage of the infected joint and intravenous antibiotics to combat the joint infection. Joint aspiration is often performed to relieve pressure and analyze the joint fluid.

Both conditions require urgent medical attention, as they can lead to severe complications if left untreated. Accurate diagnosis and appropriate treatment are crucial for a successful outcome. It's important to consult a healthcare professional for a proper evaluation and management of these conditions in infants and young children.

Conclusion

This comparative review sheds light on the distinct clinical presentations, diagnostic challenges, and therapeutic approaches associated with infantile osteomyelitis and septic arthritis. While both conditions demand early recognition and intervention to prevent long-term complications, understanding their unique characteristics is crucial for accurate diagnosis and effective management.

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Dr. Anuj Gupta
Dr. Anuj Gupta

Spine Surgery

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