iCliniq Logo
HomeHealth articlesPulmonology (Asthma Doctors)lung damage

Bronchopulmonary Dysplasia: Causes, Symptoms, and Management

Verified data
0

3 min read

Share

Outline

Bronchopulmonary dysplasia is a lung disease in newborns. Read the article to learn about the symptoms, diagnosis, and treatment of bronchopulmonary dysplasia.

Written byDr. Saberitha

Medically reviewed byDr. Kaushal Bhavsar

Published At October 7, 2022
Reviewed AtJuly 19, 2024

Introduction

Bronchopulmonary dysplasia is a chronic lung condition that affects children, especially newborns. Premature babies born before ten weeks of the delivery date are more prone to this lung condition. Preterm birth newborns with weights less than two pounds are also affected by bronchopulmonary dysplasia due to incomplete lung development. This is not a congenital condition, as it occurs after birth.

What Is Bronchopulmonary Dysplasia?

Bronchopulmonary dysplasia causes long-term breathing problems in premature dysplasia. This condition often results in poor growth and development. There is no cure for this condition, but it can be treated, and most babies live long and healthy lives.

What Are the Causes of Bronchopulmonary Dysplasia?

  • Lung Disorder: Premature babies born with previously existing lung diseases like respiratory distress syndrome or undeveloped lungs are affected by bronchopulmonary dysplasia.

  • Steroids: Premature babies born without receiving steroids are at increased risk of bronchopulmonary dysplasia.

  • Oxygen Insufficiency: The newborns with oxygen deprivation during birth require ventilatory support for breathing.

  • Family History: The genetic inheritance of lung abnormality causes bronchopulmonary dysplasia.

  • Nutritional Deficiency: Premature newborns have nutritional deficiencies and immunity disorders. They are likely to acquire respiratory illnesses or microbial infections faster.

  • Pregnancy: The conditions that affect newborns during pregnancy include preeclampsia (increased blood pressure) and infections.

What Are the Symptoms of Bronchopulmonary Dysplasia in Newborns?

Every newborn is different and has its symptoms. The symptoms vary depending on the severity of bronchopulmonary dysplasia and the time of premature birth. The few symptoms are as follows;

  • Respiratory Illness: The babies born with respiratory ailments lead to bronchopulmonary dysplasia at the 36th week. The newborn has breathing problems with the flaring of the nostrils.

  • Cardiac Problems: The newborns have irregular heartbeats, which can eventually lead to heart failure. The newborn pulls the chest during each respiratory cycle.

  • Feeding: It is difficult to feed newborns, as they throw tantrums due to breathing problems. The newborn's breathing is rapid and shallow.

  • Growth: There is a developmental delay in the organs and parts of the body. Height and weight are underdeveloped in premature babies compared to normal babies.

  • Sensory Problems: The babies have problems with their vision and hearing. Grunting sounds are heard during breathing due to lung defects.

What Are the Stages of Bronchopulmonary Dysplasia in Newborns?

Based on the progress of the disease in bronchopulmonary dysplasia, it is classified into four stages. They are as follows;

  • Stage 1: The initial stage is also known as respiratory distress syndrome. In this stage, the newborn is unable to get enough oxygen during breathing, which eventually leads to bronchopulmonary dysplasia.

  • Stage 2: The frequent inhalation of oxygen from the ventilators damages the alveoli (tiny air sacs), damages the lungs, and results in swelling in the lung tissue.

  • Stages 3 and 4: These stages have severe long-term symptoms. Newborns have inflammation in the blood vessels of the lungs (pulmonary vessels). The oxygen-carrying capacity is reduced in newborns due to the rupture of blood vessels. This eventually increases blood pressure and causes pulmonary hypertension.

How Is Bronchopulmonary Dysplasia Diagnosed in Newborns?

The pediatricians decide on the diagnostic test based on the problem associated with lung development. The diagnostic tests are as follows;

  • Chest X-Rays: X-rays are taken for babies with bronchopulmonary dysplasia to observe the condition of the lungs, airways, ribs, and chest.

  • Pulse Oximeter: The pulse oximetry test measures the oxygen level in newborns' blood, which is useful for assessing lung function.

  • Arterial Blood Gas Test: An arterial blood gas test measures the pH, oxygen, and carbon dioxide levels in the bloodstream. Any alterations in the blood acidity level reveal an abnormality in the newborn's lungs.

What Are the Various Treatment Methods for Newborns With Bronchopulmonary Dysplasia?

If premature delivery is necessary, then treat the pregnant woman with steroids to avoid the risk of bronchopulmonary dysplasia. Though bronchopulmonary dysplasia cannot be cured completely, the symptoms can be managed with the help of the following measures;

  • Healthy Intake: Premature babies require nutrition and 140 to 150 calories daily. Breast milk boosts immunity and improves lung conditions, so formulated breast milk must be provided for underweight babies to prevent bronchopulmonary dysplasia.

  • Avoid Fluids: Try to restrict the fluid intake of infants because it reduces swelling in the lung tissue. Excess fluid around the lungs of newborns results in lung collapse. So avoid excess fluids.

  • Ventilatory Support: The baby cannot breathe due to lung abnormalities. The oxygen is provided by ventilators in hospitals. After discharge, the baby might require ventilator support in the home as well. The medical provider uses a less invasive technique to deliver oxygen to avoid injury to the newborn's airways.

  • Medications: Bronchodilators open the air passages and facilitate breathing in newborns. An artificial surfactant prevents lung collapse in infants by preventing the rupture of the small air sacs (alveoli). Medical professionals prescribe diuretics to reduce fluid accumulation around the lungs. Untreated bronchopulmonary dysplasia in newborns is life-threatening.

How to Prevent Lung Disorders in Newborns?

Pregnant women should take good prenatal care for the welfare of the baby.

  • A healthy pregnancy can avoid premature birth and lower the risk of respiratory illnesses.

  • A pregnant mother should get a healthy diet and avoid smoking alcohol or cocaine until delivery.

  • Pregnant women with lung issues or any other medical conditions must take prior treatments as it influence bronchopulmonary dysplasia in newborns.

  • Apart from bronchopulmonary dysplasia, the underlying lung diseases must be identified in newborns and treated earlier to avoid future complications.

Conclusion:

In most cases, newborns are admitted and treated in the hospital until recovery to avoid breathing problems. Due to awareness, the prevalence rate of bronchopulmonary dysplasia has recently been reduced. The appropriate treatment at the initial stages can increase the survival rate of premature babies. The parents and pediatrician must observe developmental delays and symptoms periodically.

Listen to related tracks in our music library

Frequently Asked Questions

The following are the potential complications of bronchopulmonary dysplasia:
- Respiratory infections, such as pneumonia, bronchiolitis, and RSV (Respiratory Syncytial Virus).
- Developmental issues like stunted growth.
- Poor expansion of lungs.
- Pulmonary hypertension (raised blood pressure in the arteries of the lungs).
- Chronic lung and breathing conditions such as scarring or bronchiectasis.
The following individuals are at greater risk to develop bronchopulmonary dysplasia:
- Infants suffering from patent ductus arteriosus.
- Individuals showing lung abnormalities such as lung angiogenesis.
- Individuals involved in smoking, drug abuse, and placental anomalies.
- Inflammation of the fetal membranes is known as chorioamnionitis.
The following strategies are to be utilized to prevent bronchopulmonary dysplasia:
- Non-invasive Ventilation: It helps by providing an adequate amount of oxygen.
- Oxygen Saturation Targets: These activities maintain oxygen levels in the body.
- Caffeine and Vitamin A: These supplements are useful in maintaining the oxygen levels in the body, and act as antioxidants.
- Patent Ductus Arteriosus Closure: It is done to prevent long-term lung damage.
- Macrolides and Antenatal and Postnatal Steroids: These are used to improve fetal lung maturity and surfactant treatment to prevent respiratory distress syndrome.
There is no cure for bronchopulmonary dysplasia. This disease can be treated. A number of patients survive after getting adequate treatment but some patients die also.
Genetics plays an important role in causing bronchopulmonary dysplasia. The following factors have altered and induced the disorder in the individuals:
- IGF-1 (Insulin-like growth factor).
- VEGF (Vascular Endothelial Growth Factor).
- TGF-B (Transforming growth factor).
Babies tend to develop severe symptoms during infancy and early childhood. The symptoms of bronchopulmonary dysplasia start receding by two to three years of age. Therefore, the treatment ends by the age of five years.
Respiratory distress syndrome develops within the initial hours of birth in infants. Bronchopulmonary dysplasia appears within one or two weeks of birth. Respiratory distress syndrome occurs when there is a lack of surfactant in the lungs. Bronchopulmonary dysplasia is a breathing disorder.
Bronchopulmonary dysplasia usually does not get worse with age. But it gets associated with other lung disorders even after getting treated entirely. There is an improvement seen due to the treatment given.
Lung development can be done by following a proper and nutritious diet. It includes all the essential nutrients such as carbohydrates, proteins, and fatty acid components required to form the surfactant. The affected babies must be given a balanced diet in a semi-solid or solid form.
Bronchopulmonary dysplasia is not curable. It can be treated. The main objective of the treatment is to grow and develop the lungs of the affected babies.
Yes, one can be born with bronchopulmonary dysplasia. It is a congenital condition. In this condition, the individual becomes affected before birth.
Yes, a baby can survive with one lung. Basically, the lungs are required to provide sufficient oxygen and withdraw an adequate amount of carbon dioxide for the body to remain healthy. Doctors perform pneumonectomy to remove the affected lungs but the individuals can survive with one lung also.
Yes, changes in brain development have been noticed in babies suffering from bronchopulmonary dysplasia. The three main parts: the amygdala, the hippocampus, and the orbitofrontal complex show smaller growth than normal. Brain development is hindered by the disease as abnormal growth occurs.
Bronchopulmonary Dysplasia is induced by injury to the fragile tissue of the lungs. This damage most often arises in newborns who have needed prolonged therapy with supplementary oxygen and mechanical ventilation. Such therapies create disruptions in the formation of surfactants.
In most cases, the babies start showing improvement within two to four months of the treatment. The symptoms start to disappear within two to three years. The treatment usually lasts around five years.

Tags:

bronchopulmonary dysplasialung damage

Ask your health query to a doctor online

Pulmonology (Asthma Doctors)

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.