What can be the reason for dark inner thighs and buttocks in an overweight female?

Hello,

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I understand your concern and would be happy to help. You have acanthosis nigricans more prominently, pseudoacanthosis nigricans. Acanthosis nigricans is a skin disorder with dark, thick, velvety skin in body folds and creases. The skin becomes dark, velvety, and thick, in the back and sides of the neck, armpits, thighs, elbows, and knees. It appears very slowly and does not cause symptoms other than skin changes. It typically occurs in individuals younger than 40, may be genetically inherited, and is associated with obesity or endocrinopathies, like hypothyroidism, acromegaly, polycystic ovary disease, insulin-resistant diabetes, or Cushing's disease. Most cases of acanthosis nigricans are associated with obesity or are idiopathic. This is likely because of insulin resistance and is more common in dark-skinned people. This is also known as Pseudo-Acanthosis Nigricans. Acanthosis nigricans is likely to improve in circumstances where a known cause is removed. For example, obesity-related pseudoacanthosis nigricans will improve with weight loss. People with acanthosis nigricans, in general, should be screened for diabetes. Weight loss and controlling blood glucose levels through exercise and diet often improve the symptoms. I suggest you to use topical Tretinoin 0.05 % cream once daily at night to help lighten pigmentation. You must also practice weight loss, exercise, and diet management. Alpha-lipoic acid has shown to increase insulin sensitivity and thereby reverses pseudo-acanthosis nigricans resulting from insulin resistance states like obesity and diabetes. It is commercially available with prescription for acanthosis nigricans. Tablet Nexna (Alpha-lipoic acid) twice daily is prescribed for acanthosis nigricans. I suggest you to continue with tablet Glycomet and Yasmin. I hope this helps. Thank you.