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What does normocytic RBC with anisocytosis mean?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I have normocytic normochromic RBC with anisocytosis.

Kindly help.

Hi,

Welcome to icliniq.com.

I can understand your concern. I have seen the attached report (attachment removed to protect patient identity).

In the attached report, the lymphocyte count is high. High lymphocytes are usually seen in viral infections. There are other causes of lymphocytosis as well. But you need to repeat CBC (complete blood count) again after one week to check the lymphocyte count. The peripheral smear finding is normal, so do not worry about any abnormal cells. However, revert back to me with a repeat CBC after one week.

The size and hemoglobin content in red blood cells are mentioned as normocytic normochromic. So do not worry about normochromic normocytic RBC, which is absolutely normal.

I hope this helps you.

Please follow up if you have any doubts.

Thank you.

Patient's Query

Hi doctor,

Thank you for your reply.

I was worried about the word anisocytosis. However, do you want me to take any iron supplements, as I have read anisocytosis is anemia? And for sure, I will take the CBC in a few days and get back to you.

Please guide.

Hi,

Welcome back to icliniq.com.

The word anisocytosis means variation in the size of red blood cells. Mild anisocytosis can be seen normally as well. If it is marked, then an iron supplement is needed. Marked anisocytosis is seen in iron deficiency anemia.

But in your case, it is mild, and you have predominant normocytic means normal-sized RBC. So do not worry about anisocytosis. It is not a matter of concern if the hemoglobin level is normal. If you have a value of hemoglobin, then attach that report. In your attached report, the Hb value is not mentioned. I will check your lymphocyte count after a few days.

I hope this helps.

Please follow up if you have any doubts.

Thank you.

Patient's Query

Hi doctor,

Thank you for your reply.

I am attaching the full report and will repeat the test in a few days and will get back to you.

Please guide.

Hi,

Welcome back to icliniq.com.

I have checked your attached report (attachment removed to protect patient identity).

Your hemoglobin level and RBC are within range. So do not worry about anisocytosis. You are not having iron deficiency anemia. So do not start iron supplements. Do not worry about anisocytosis. Drink lots of water. Take healthy foods like green leafy vegetables and fruits more.

Our main concern is lymphocytes which will check after a few days.

I hope this helps.

Patient's Query

Hi doctor,

Thank you for your reply.

Will get back to you with reports in a few days.

Please guide.

Hello,

Welcome back to icliniq.com.

Sure, I will answer as quickly as possible whenever you post your repeat CBC. Keep in touch for further doubts.

I hope this helps you. Please follow up with the reports.

Thank you.

Medically reviewed byDr. Vinodhini J.

Published At July 9, 2020
Reviewed AtApril 16, 2026

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