HomeAnswersSpine healthankylosing spondylitisMy friend has been detected as HLA-B27 positive and she has back pain. What does it mean?

What is meant by HLA-B27 positive?


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Medically reviewed by

iCliniq medical review team

Published At November 4, 2023
Reviewed AtNovember 27, 2023

Patient's Query

Hello doctor,

My friend has been detected as HLA-B27 positive and her ESR is 33. She has back pain for the last four years but recently she is feeling more pain. We took an x-ray of the lower spine and it appears normal. She is only 31 years old. There is no one in the family (maternal or paternal) who has faced this problem.

At the moment doctors have given her Dolo 650 tablet for the pain and calcium and vitamin D3 tablets. When she takes Dolo she feels relieved for 24 hours but the pain will start again.

What is this condition? Please help.

Thank you.


Welcome to icliniq.com.

I read your query and can understand your concern.

This is suggestive of a condition called ankylosing spondylitis. In this, there will be stiffness of the joints and calcification of tendons. This disease can be treated but cannot be cured. I suggest you stop Dolo and take (consult with your physician and take the medications only with their consent).

  1. Tablet Indomethacin 25 mg thrice daily for 10 days after food.
  2. Tablet Rabeprazole 20 mg twice daily for 10 days after food.
  3. Continue calcium and vitamin D tablets.

Take these tablets only if your friend is not allergic to them, or not a known case of bronchial asthma.

Physiotherapy is the mainstay of this disease treatment. You need to do stretching exercises of all the joints of the body, to keep it mobile. Swimming is one of the best exercises for you.

Thank you.

Probable diagnosis

Back pain with hla b27 positive

Regarding follow up

Follow up with xray images for an accurate advice

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Sharoff Lokesh Mohan
Dr. Sharoff Lokesh Mohan

Orthopedician and Traumatology

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