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HomeAnswersPsychiatryantipsychotic withdrawalHow can I gradually withdraw myself from taking the medicine Quetiapine?

I take Quetiapine XR 400mg.How can I gradually withdraw?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Bharat Udey

Medically reviewed by

iCliniq medical review team

Published At June 30, 2015
Reviewed AtNovember 9, 2022

Patient's Query

Hello doctor,

I take Quetiapine XR 400mg. How can I gradually withdraw?

Answered by Dr. Bharat Udey


Welcome to icliniq.com.

Quetiapine is an atypical antipsychotic, with a half-life of less than 24 hours. It has a benefit of not causing extrapyramidal side effects. However, it can cause sedation, postural hypotension, and urinary complaints.

Although it does not cause any withdrawal symptoms, it is recommended to stop gradually by tapering over a period of time. As you are taking 400 mg XR formulation of Quetiapine, you can taper it by 100 mg every 2 days until you reach a dose of 100 mg, when you reach 50 mg, take 50mg for one more day and then stop.

However, if you are taking Quetiapine for some psychotic conditions or acute mania/ BPAD (Bipolar Affective Disorder), I would suggest you to consult your treating psychiatrist before tapering your medications, as at times unsupervised tapering can lead to the reappearance of the symptoms.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Bharat Udey

Dr. Bharat Udey


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