Tapering Drug Dose

Tapering drug dose is known as a gradual reduction in the amount of a drug. When the drug is stopped suddenly, it can cause unnecessary withdrawal symptoms.

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I have a history of prostate cancer, and my PSA levels increased after stopping Leuprolide. What should I do?

Query: Hello doctor, I had stage III prostate cancer fifteen years back. My doctor wanted to stop the tablet Leuprolide and see what happens and then have a PET scan. My PSA increased to 1.3 quickly after stopping Leuprolide. I have attached the PET scan report. Kindly review and revert.   Read Full »


Dr. Saurabh Subhash Pandya

Answer: Hello, Welcome to icliniq.com. I read your query and can understand your concern. Post-surgery radiotherapy was given, and Leuprolide was started. This suggests either lymph nodes or margins were positive, and there may have been a prior rise in PSA (prostate-specific antigen). So I suggest conti...  Read Full »

How can I gradually withdraw myself from taking the medicine Quetiapine?

Query: Hello doctor, I take Quetiapine XR 400mg. How can I gradually withdraw?  Read Full »


Dr. Bharat Udey

Answer: Hello, Welcome to icliniq.com. Quetiapine is an atypical antipsychotic, with a half-life of less than 24 hours. It has a benefit of not causing extrapyramidal side effects. However, it can cause sedation, postural hypotension, and urinary complaints. Although it does not cause any withdrawal symp...  Read Full »

I want to stop taking Aspirin. Should I bring it down slowly or can I stop taking it?

Query: Hello doctor, I have been taking tablet Aspirin 325 mg twice daily for years because I have a phobia about blood clots. Is it safe to just suddenly stop this or do I need to wean off to be safe?  Read Full »


Dr. Isaac Gana

Answer: Hello, Welcome to icliniq.com. I would like to know as to why did you take Aspirin for so long and was the medication prescribed by a doctor? It is risky to stop at once. Do you have a history of high blood pressure?  Read Full »

How to avoid feeling low after stopping depression medicine?

Query: Hi doctor, When my father passed away, I was diagnosed with major depression and had been on medication Lexapro for about a year. My psychiatrist recently stopped my medications as I was feeling rather normal. Shortly, I came for holidays overseas hoping to become more relaxed and at ease. But, I am...  Read Full »


Dr. Awadhesh P. Singh Solanki

Answer: Hi, Welcome to icliniq.com. I can understand your situation. You were taking Lexapro, which contains Escitalopram, since a long time. Sudden stopping of this drug causes withdrawal symptoms like poor sleep, low mood, loss of interest in cheerful activities, etc. I will suggest you make yours...  Read Full »

Can you stop taking Raciper Plus suddenly?

Query: Hi doctor, I have been taking Raciper plus for a year now. How can I stop?  Read Full »


Dr. Sandeep V. Nair

Answer: Hi, Welcome to icliniq.com. Raciper Plus is a proton pump inhibitor (Esomeprazole) and sustained release Domperidone combination. It is usually prescribed for acid peptic disease or GERD (gastroesophageal reflux disease). First of all, you can stop if your symptoms are under control. Since you h...  Read Full »

What is the recommended duration to take antihistamines for urticaria or hives?

Query: Hello doctor,I have urticaria or hives and have been under antihistamines for five weeks. For the last six days, I had to take a high dose of tablet Fexofenadine Hydrochloride 180 mg four times daily. The redness on my skin has disappeared. Can I stop taking the medicines? If so, should it be done g...  Read Full »


Dr. Shyam Kalyan. N

Answer: Hello, Welcome to icliniq.com. 1) It is not safe to abruptly stop the antihistamines (medications for allergy); the best way is to taper it down gradually. 2)As you take tablet Fexofenadine 180 mg four times daily, make it thrice daily for two days, then twice daily for two days, and once daily f...  Read Full »

I experience severe side effects of Seroquel, which affect my mental and physical well-being. How to taper the dose?

Query: Hi doctor,I have been on Seroquel for four years, and my mental health and quality of life have deteriorated. When I was taking Risperidone, everything was great. But now, I experience severe side effects with Seroquel, and I cannot stop taking it since I experience withdrawal symptoms. I currently ...  Read Full »


Dr. Vishal Anilkumar Gandhi

Answer: Hi, Welcome to icliniq.com. I went through your query and understood your concern. Why are you on such a high dose of Seroquel (Quetiapine)? Kindly give me the details about your mental illness. You can taper the dosage gradually, but it takes time. In addition, you can take Benzodiazepine (anti...  Read Full »

How to reduce the dosage and gradually stop my medicines without side effects?

Query: Hello doctor,I am a 23 year old male. I want to quit my medicines permanently. I am taking Valkem OD 500, Soltus 100 mg, Flunil 20, and Ativan 2 mg. How to reduce the doses and completely stop taking these medications without any side effects?  Read Full »


Dr. Ashaq Hussain Parrey

Answer: Hello, Welcome to icliniq.com. I went through your post. You are on Divalproex (Valkem) which is used for epilepsy; in addition, you are on antidepressants and antipsychotic meds. Firstly, if you have a seizure disorder, for which you are taking Valkem, then your EEG (electroencephalogram) shoul...  Read Full »

Is it safe to discontinue tablet Escitalopram to avoid drug addiction?

Query: Hello doctor, I have been taking Escitalopram for one year for OCD and depression. It made me feel normal again. Recently, I stopped taking antidepressants, and I feel a bit depressed again. I have not experienced any side effects due to the medication. So, is it fine if I continue being on antidep...  Read Full »


Dr. Awadhesh P. Singh Solanki

Answer: Hi, Welcome to icliniq.com. Thanks for your query. No, Escitalopram does not cause dependence and tolerance. However, one should not discontinue it all of a sudden. We need to taper it gradually before stopping. I hope my answer helped you. Kind regards.  Read Full »

I want to taper the dose of capsule Pexep Plus 12.5 mg. Can you please help?

Query: Hi doctor, I was prescribed a capsule Pexep Plus (Clonazepam and Paroxetine) 12.5 mg for two months during jaundice. Now I have recovered from jaundice, and it has been more than three months. I want to know if I can taper the medication now. Unfortunately, I followed cold turkey, and now I am getti...  Read Full »


Dr. Vishal Anilkumar Gandhi

Answer: Hi, Welcome to icliniq.com. You should gradually taper your medication (consult with a specialist doctor, talk with him or her and take medicine with consent). For example, I suggest you take half a tablet Pexep Plus (Clonazepam and Paroxetine) 12.5 mg for four to six weeks and then take the same...  Read Full »

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