Q. Why am I feeling hand cramps and leg twitches after stopping Seroquel?

Answered by
Dr. Anshul Varshney
and medically reviewed by iCliniq medical review team.
Published on Nov 28, 2016 and last reviewed on: Oct 09, 2018

Hi doctor,

I was on 600 to 900 mg of Seroquel for at least 5 years. I contacted my psychiatrist about stopping the medication when I realized it had been prescribed for a condition that I do not have. My doctor was not open to this conversation and I unwisely decided to stop the medicine on my own. I did a fair amount of research prior to my titration and even went so far as to map out my titration schedule on a calendar. My main withdrawal concerns were anxiety, rapid heartbeat and insomnia. After a few days of titration when I realized I was not having any withdrawal effects I basically stopped cold turkey.

About two weeks later, I experienced a weird cramping sensation in my hand. Based upon my rigorous physical activity, I assumed that I was dehydrated. The symptoms persisted for a few days and I decided to see a doctor. My laboratory reports ruled out an electrolyte imbalance, but I decided to start daily calcium and a multivitamin regimen at the recommendation of the doctor. Then, my symptoms have gotten out of control. I have had burning, pins and needles, tingling, numbness and cramping in both hands and feet. Recently, in the past few days, I have started to experience muscle twitches in both legs. I have seen a primary care physician and a neurologist. Also, I have had numerous laboratory tests and they were all normal. My electrolytes are good, no vitamin deficiency, liver and kidney function are good, thyroid good, no rheumatoid arthritis, no muscle wasting and I seemed to pass the in-office neurological examination.

I feel like my electrical system has been misfiring for weeks. Every day, it is something different. In the past few months, I guess the good news (I think) is that the pain is less. But, what concerns me is that this is not stopping and now my legs are twitching. My neurologist seems to think this is all because I stopped Seroquel suddenly. In a sense, this is somewhat relieving. But, at the same time, I have not been able to find any other reports of similar withdrawal symptoms. I did not have any of the common withdrawal symptoms.

My two main concerns are will this ever permanently stop? What happens if it continues to progress? Lastly, what else do I need to do to rule out the diagnoses? I am a very active and healthy 43 year old woman. I am not on any regular medication. I tend to agree with the neurologist's theory as the symptoms coincided with the termination of Seroquel. Aside from what I am experiencing now, the sickest I have ever been is when I had pneumonia. Please help me.

Dr. Anshul Varshney

Critical Care Physician Diabetology General Medicine Internal Medicine Medical Gastroenterology Nephrology Pulmonology (Asthma Doctors) Rheumatology


Welcome to icliniq.com.

We are here to help you.

  • This is called as tension type headache and is a part of anxiety only.
  • Stopping any antidepressant is usually a difficult task and is usually accompanied by one or other symptoms as withdrawal. It should be stopped once you have been doing well with lots of meditation.
  • As far as your questions are concerned, yes, you will be able to stop it. But, before that, you would need to keep a control on your mind by doing meditation.
  • For such headaches, I would recommend Amitriptyline for a short course.
  • Make sure you are sleeping on time for at least 8 hours. Also, avoid coffee, cheese and fast food.

For further information consult a neurologist online --> https://www.icliniq.com/ask-a-doctor-online/neurologist

Also Read Answers From:

Related Questions & Answers

Generalized Anxiety Disorder(GAD)

Article Overview: A 35-year-old woman came to me with a chief complaint of muscle tension. She stated that she has experienced a considerable amount of muscle tension her entire life, but it has become increasingly worse over the last 12 months. Read Article

The above mentioned patient is suffering from Generalized Anxiety Disorder (GAD). GAD can be defined as anxiety and worry about several events and activities for a majority of the day. The anxiety and worry of GAD differs from normal anxiety by its excessiveness, the difficu...  Read Article

How does yoga help senior citizens?

Query: Hi doctor, What are the health benefits and trends for yoga for senior citizens? Are there studios that have classes or professionals that cater to this demographic? Why choose yoga over other forms of fitness and stretching?  Read Full >>

Dr. Vinod Kumar Goyal
Ayurveda Specialist

Answer: Hi, Welcome to icliniq.com. Yoga is of two types. One for physical exercises called asanas and the second one is meditational yoga. Both have tremendous benefits for life and health. Physical yoga regulates body glands, hormones and cures many diseases of the body. For different persons and condit...  Read Full

My sister has a headache that does not subside with pain medications. Please help.

Query: Hello, My sister has headaches from the last six months. Earlier, it was random, but from the last two months, it is continuous. The MRI is normal and no medicines are working. Please help.  Read Full >>

Dr. Anshul Varshney
Internal Medicine Physician

Answer: Hello, Welcome to icliniq.com. It could be a migraine or tension type headache. Please revert with the following details: Are the headaches one-sided or on both sides?  Are the headaches pulsating in nature?  Is the frequency daily or intermittent?  Is it associated with nausea or vomiting? Reve...  Read Full



Ask your health query to a doctor online?

Ask a Neurologist Now

* guaranteed answer within 4 hours.
Enter Your Health Query
You can upload files and images in the next step.



Disclaimer: All health Q&As published on this website is not intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek the advice from your physician or other qualified health-care providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.