Q. Is Aripiprazole safe for my father who is 65 years old?
Hello doctor,
My father is 65 years old. He has bipolar disorder for 40 years. He also has diabetes. He is taking medicine for high blood pressure.
For a very long time, he took lithium 1000 mg and oxcarbazepine 900 mg. 2-3 episodes used to happen, normally of long manic spell followed by gloomy/not so active spell. He stopped lithium due to toxicity, as even low dose was toxic. He started 200 mg quetiapine at night. In manic spell, he used to take up to 30 mg aripiprazole for 2-3 months.
Considering his age and other medical conditions, what should be the right combination of medicine? Is aripiprazole safe? (it is very effective in mania for him) Now he has stopped aripiprazole, and he is fine. But he is complaining of restlessness sometimes. He feels like not wanting to sit in a place. What should be given to him in this post mania phase? Please ask for any more details if you require.
Hi,
Welcome to icliniq.com.
I have read through your query in detail. Please find my observations below.
Medicines for mental health conditions should be taken under the strict supervision of the psychiatrist. As mentioned above, lithium toxicity is a serious concern and it is good that you have stopped lithium due to toxicity.
Quetiapine is an atypical antipsychotic medication and studies have shown that it is a safe and effective medication for the elderly. The side effects are less when the patient takes Quetiapine.
Transient hypotension, dizziness, and somnolence are the only side effects in patients and is seen rarely. Long term use of Quetiapine has shown no serious side effects in the elderly.
Aripiprazole is good medicine but might cause agitation and activation in about 8 percent of elderly people who take it. Studies show that in most patients Aripiprazole can be continued at a dose of 10 to 15 mg/day. Aripiprazole has less metabolic side effects than other medicines.
Side effects of Aripiprazole include dizziness, weakness, lightheadedness, nausea, vomiting, stomach upset, tiredness, excess saliva or drooling, choking or trouble in swallowing, blurred vision, headache, anxiety, weight gain, drowsiness, sleep problems (insomnia) and constipation.
There is a little increase in the risk of stroke in the elderly due to the intake of antipsychotic medicines, though this is very less. It is very important to go into details of patient problems when prescribing and changing doses of medicines.
I hope your father is managing well with his diabetes and blood pressure.
Considering the above, it is best to prescribe medicines based on benefit and risk. Some patients might do well without medicine without much bipolar symptoms and in the absence of frequent attacks, however many require medicines like your father.
There is no fixed regimen over one medicine being better than the rest but medicine like Aripiprazole has fewer side effects.
Can you please let us know the treatment he has undertaken in the last 2 years, including medicine name and duration for which it was taken, dose, symptoms, and improvements.
Thanks a lot doctor.
In addition to the above information, I forgot to mention that in manic phase he also takes 2 mg of Rivotril for sleep. In the past 2 years his health is more or less the same.
Hi,
Welcome back to icliniq.com.
1. Please change the medications only under the recommendation of the treating psychiatrist and after clinical evaluation. The following are only suggestions based on information given by you. Patients with diabetes and hypertension have a limited choice of antipsychotic medications and require medications to be taken on an individual basis.2. Oxcarbazepine is a good alternative to lithium. However, if he is taking Quetiapine, then that is better.3. Right now:
- Either Quetiapine or Aripiprazole (anyone medicine and not both) requires to be given although he is in post mania. If nothing is given, then there is a higher chance of relapse.
- Rivotril (Clonazepam) might be given in split doses, 0.25 mg in the morning and 0.5 mg at night for restlessness and disturbed sleep. 2 mg is a slightly higher dose and is usually given only if patients develop tolerance. This has to be taken for 2 weeks and subsequently tapered and terminated. This is because few elderly patients might have side effects with long term use of Rivotril.
Was this answer helpful?
|Same symptoms doesn’t mean you have the same problem. Consult a doctor now!
Related Questions:
Do my symptoms indicate bipolar disorder or schizophrenia?
To me, it seems more closely related to schizophrenia or schizoaffective disorder ... Schizophrenia and schizoaffective disorder diagnosis are made only when there are criterias of disease which Read full
Mirap and Clonazepam prescribed for anxiety and depression, Is it fine to take?Age 40Y, Male, minor knee pain sometime ,TAK Tak Sound when sit on kness, no injury , Family Heridatory , suggest precaution in diet or medicine for future Read full
Taking medicines for bipolar disorder, but unable to sleep. Is there any suggestions?When i go to the toilet i pass my stool and then when i wipe there is blood on the tissue Read full
Also Read Answers From:
Comprehensive Medical Second Opinion.Submit your Case
iCliniq's FREE Newsletters
Expert-backed health and wellness information, delivered to your email.
Thank you for subscribing to our Newsletters!
Also Read
PCOS and Liver Problems
The hormonal imbalances in polycystic ovary syndrome could cause liver diseases. Read the article to know the relationship between these medical conditions. Read more»
Inferior Alveolar Nerve Lateralization Technique
The inferior alveolar nerve lateralization technique is a surgical lateralization technique to reposition the nerve. Read the article to know more about this. Read more»
COVID-19 and Ebola: Similarities and Differences
This article gives a comparison and broader overview of the outbreak of the two deadliest diseases that showed a greater incidence over the last two decades. Read more»
Ask your health query to a doctor online?
Ask a Geriatrician Now* guaranteed answer within 4 hours.