HomeAnswersNeurologybipolar disorderCan you please tell me the findings after going through my PET CT scan images?

How to treat pseudo-Parkinsonism in me?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Hitesh Kumar

Medically reviewed by

iCliniq medical review team

Published At April 3, 2023
Reviewed AtJuly 18, 2023

Patient's Query

Hello doctor,

I was diagnosed with bipolar I and placed on the tablet Lithium. But that resulted in massive tablet polydipsia. So, it was replaced with the tablet Haloperidol. Next, it was replaced with tablet Sodium Valproate. Two years later a specialist in involuntary moments prescribed me Tablet Quetiapine to get over the tardive dyskinesia which had given rise to massive problems. Five to six years later it improved my movements, my speech, and my mental functioning and all of which had been affected negatively by the 20 years of the tablet Haloperidol. Then I changed over to tablet Lamotrigine and Oxcarbazepine. Seven years ago, while crossing a railway bridge, I faced my extreme balance problem. I did not identify the source of it until recently when I discovered it to be caused by low dopamine. I reasoned it was my pseudo-parkinsonism at play. I started on tyrosine, tryptophan, vitamin B1, and velvet beans to increase the production of dopamine. First, can you look at the PET CT scan images and tell me what are the issues with my brain as shown by the scan? The substantia nigra is the part that deals with dopamine. Is it affected? And by how much? What other observations would be significant in my case?

Please advise me about the next steps of treatment.

Answered by Dr. Hitesh Kumar

Hi,

Welcome to icliniq.com.

I understand your concern.

As per your description history, you have been on tablet Haloperidol for many years. But your history did not describe any symptoms to mimic parkinsonism (which you said to be pseudo-parkinsonism). I would like to know those symptoms in a time sequence manner. Currently, what medications and at what dosage are you taking? The FDG PET (fluorodeoxyglucose (FDG)-positron emission tomography (PET)) scan which you got is reported as "No focal areas of hypometabolism in brain parenchyma". With this available history, I feel there may be the possibility of drug-induced extrapyramidal symptoms. Physical consultation would be appropriate for such a situation, instead of online chat consultation. Also, FDG PET is not diagnostic for such a condition. FDG PET scan looks at glucose uptake in cells, not look dopamine. To look dopamine pathway, Tc - Trodat scan and Dopa-PET would be more appropriate. But that also is not a confirmatory diagnostic test. It has only a corroborative significance with clinical judgment. The main judgment would be clinical only. Real parkinson's (Idiopathic parkinson's disease) is also diagnosed mainly clinically, not by PET scan.

Patient's Query

Hi doctor,

Thank you for the reply.

A laboratory urine test confirmed a low dopamine level. When I went off the tablet Haloperidol my movements were stiff, my speech unintelligible, and my mind was slow in functioning along with facial, buccal, and hand involuntary movements. Tablet Quetiapine normalized my speech, improved my mental agility, and relaxed my movements, Of course, the passage of time must have helped too. Would a video consultation substitute for a physical one? Else, what type of neurological sub-specialty do I look for in my town? Is parkinsonism a sub-specialty now common in here? The effect of the nutritional treatment outlined above sparked mental clarity, speed, coherence, and some improvement in balance. What can I add to speed up balance recovery? Is a new combination of tablet Levodopa and Carbidopa advisable for me? Please name some hospitals and doctors for further treatment.

Answered by Dr. Hitesh Kumar

Hi,

Welcome back to icliniq.com.

Urinary dopamine level is not a confirmatory test for parkinsonism. The decision of medicines will be feasible by physical examination and detailed long history. Physical consultation seems to be needed in your case. You can look out for a movement disorder specialist, a subspecialty of neurology. Till now, as per my knowledge, stem cell treatment is not approved for parkinsonism. If it is idiopathic parkinson's disease, deep brain stimulation is a treatment option, but that can not be decided on chat or video consultation.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Hitesh Kumar
Dr. Hitesh Kumar

Neurology

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