This article discusses the historical aspects of Parkinsonism and, the evidence based approaches currently available for its treatment. Focus is also given to the non-motor manifestations and the neurobehavioral abnormalities. Both medical and surgical modalities of treatment find a mention.
Parkinsonism is a syndrome manifested by a combination of six cardinal features. They are:
James Parkinson in 1817 wrote '' An Essay on the Shaking Palsy'' in which he described 6 cases which had a combination of the aforementioned features. He had observed these individuals on the streets of London.
Charcot in the nineteenth century acknowledged Parkinson's contribution and referred to this condition as ''maladie de Parkinson''. A century after ''An Essay on the Shaking Palsy'' was written, loss of dopaminergic cells in the substantia nigra was identified as the pathological basis of this disease.
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Last reviewed at:
05 Sep 2019 - 2 min read
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