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Parkinson's Disease: Historical Aspects and Current Treatment Approaches

Published on Mar 20, 2015 and last reviewed on Jun 21, 2022   -  2 min read


This article discusses the historical aspects of Parkinsonism and, the evidence based approaches currently available for its treatment. Focus is also given to the non-motor manifestations and the neurobehavioral abnormalities. Both medical and surgical modalities of treatment find a mention.

Parkinson's Disease: Historical Aspects and Current Treatment Approaches


Parkinsonism is a syndrome manifested by a combination of six cardinal features. They are:

James Parkinson in 1817 wrote '' An Essay on the Shaking Palsy'' in which he described 6 cases which had a combination of the aforementioned features. He had observed these individuals on the streets of London.

Charcot in the nineteenth century acknowledged Parkinson's contribution and referred to this condition as ''maladie de Parkinson''. A century after ''An Essay on the Shaking Palsy'' was written, loss of dopaminergic cells in the substantia nigra was identified as the pathological basis of this disease.

Non-motor Manifestations of Parkinson's Disease (PD)

Neurobehavioral and Neuropsychiatric Manifestations of Parkinson's Disease

Management of the Illness

Medical and Surgical Treatments of Parkinson's Disease


Last reviewed at:
21 Jun 2022  -  2 min read




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