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Parkinson's Disease: Historical Aspects and Current Treatment Approaches

Written by
Dr. Alok Vinod Kulkarni
and medically reviewed by iCliniq medical review team.

Published on Mar 20, 2015 and last reviewed on May 11, 2021   -  2 min read

Abstract

This article discusses the historical aspects of Parkinsonism and, the evidence based approaches currently available for its treatment. Focus is also given to the non-motor manifestations and the neurobehavioral abnormalities. Both medical and surgical modalities of treatment find a mention.

Contents
Parkinson's Disease: Historical Aspects and Current Treatment Approaches

Parkinsonism

Parkinsonism is a syndrome manifested by a combination of six cardinal features. They are:

James Parkinson in 1817 wrote '' An Essay on the Shaking Palsy'' in which he described 6 cases which had a combination of the aforementioned features. He had observed these individuals on the streets of London.

Charcot in the nineteenth century acknowledged Parkinson's contribution and referred to this condition as ''maladie de Parkinson''. A century after ''An Essay on the Shaking Palsy'' was written, loss of dopaminergic cells in the substantia nigra was identified as the pathological basis of this disease.

Non-motor Manifestations of Parkinson's Disease (PD)

Neurobehavioral and Neuropsychiatric Manifestations of Parkinson's Disease

Management of the Illness

Medical and Surgical Treatments of Parkinson's Disease

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Last reviewed at:
11 May 2021  -  2 min read

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