Does a CD marker help in identifying blood cancer?

Question

Hi doctor,

I am a 25-year-old male suffering from joint pain and pain in the knees. I also have nausea, vomiting, gynecomastia, upper abdominal pain, rhinorrhea, and blurred vision. These symptoms increased over a year. I experience severe itching during exercise or bathing, and I also develop rashes with small red dots. I used to be a healthy athlete. However, things are not going well. My gastroenterologist believed that I had lupus and tested ANA. It was positive, and the antibodies were negative.

He referred me to a rheumatologist, and he believed that I did not have a rheumatic disorder. I was referred to a hematologist as I had myelocytes in the peripheral blood. A bone marrow biopsy was done, and it was negative for acute leukemia. I was recommended to see a rheumatologist again to do imaging. A bone scan was done, and it was negative. I looked at my bone marrow results, and they showed me 7.5 percent hematogones.

The hematogones are positive for CD10 and CD19. CD 10 was largely associated with many cancers, and I also had a variable expression of CD 34. A subset of hematogones is positive for MPO. Does the CD marker suggest a blood cancer? Please advise.

Thanks.

Answer 1

Hi,

Welcome to icliniq.com.

I can understand your concern.

I have gone through the attached reports of CBC (complete blood count) and flow cytometry (attachment removed to protect patient identity). Neither of these reports suggests any blood cancer. CD (cluster of differentiation) marker is helpful in the identification of blood cancer, and in the attached report, it does not seem to be blood cancer. Hematogones are lymphoid precursor cells, and they are not blood cancer.

So no need to worry about hematogones. CBC (complete blood count) does not show any abnormal malignant cells, and the total count is normal, which favors the noncancerous condition. You can upload your bone marrow biopsy report. You are complaining of multiple symptoms. Kindly mention the symptoms present at present.

I hope this information is helpful to you.

Thanks.

Answer 2

Hi,

Welcome back to icliniq.com.

I can understand your concern.

MPO (myeloperoxidase) is a special stain for the myeloid series. White blood cells are formed from the myeloid series. So MPO positivity suggests that stained cells are myeloid series cells and not lymphocyte cells. Hematogones and CD10 positivity do not mean cancer. Your CBC (complete blood count) report is normal. The presence of one to four percent of premature cells does not suggest any cancer. In blood cancer, premature cells are more than thirty percent at least.

Your JAK2 (Janus kinase 2), Exon 12, and BCR-ABL gene is negative, which excludes CML (chronic myeloid leukemia) and PV (polycythemia vera) like myeloproliferative neoplasm. The bone marrow report is also normal in the attached history. However, if you have a bone marrow report copy, then you can upload it, and I can check it. So, I do not think that you have any form of blood cancer after reviewing all the attached reports (attachment removed to protect patient identity), in my opinion.

If you have anxiety, you can develop stress with fatigue, sleep disturbance, and pain. You need to do behavioral counseling. For itching, you can do an allergic test. You can follow the advice of a rheumatologist for knee pain and joint pain.

I hope this information will help you.

Thanks.