HomeAnswersMedical Gastroenterologyblood donationI have a fever and lethargy after blood donation. Any reason?

Can blood donation lead to fever, tender liver, achy joints, and lethargy in person?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

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Published At September 18, 2022
Reviewed AtOctober 6, 2023

Patient's Query

Hello doctor,

I am a 50-year-old female weighing 150 pounds with a height of 5 feet and 4 inches and an athletic body build. I do not use drugs, nor am I on any prescriptions. I do drink about three nights a week and about 2 to 3 drinks for about three years; prior to that, only at events, I used to drink, and I quit smoking four years ago. About a year ago, I started feeling fatigue, and about four months ago, some ache and stiff joints when I wake up. I honestly just thought it was menopausal symptoms, and maybe it was. I have had a very stressful career and relationship over the last three years. I just thought I was mentally and physically exhausted. I have felt that way numerous times in the past year. I have felt I hit the wall at least three times and could not go on, but I did. So here is what has happened to me over the last three weeks and what I need your help with it. Around a month ago, I donated blood about a pint and four vials. I felt normal before, and afterward, I did feel slightly lightheaded, and I ended my day early, which is not like me. One day later, I felt better energy and drove for the weekend for about 4 hours. I felt fine overall. On this day, I tried a new supplement of 2 mg of copper; I felt fine and had a progressive dining dinner that involved four drinks over a 6-hour timeframe. The following day I felt awful. I figured it was a hangover. On the drive home, I had a headache. I took some NAC. The headache felt like a one on a scale of 1 to 10; it was just continuous and annoying. It felt like I was driving in the mountains, and even my ears popped. There were no mountains. The next day when I woke up, I felt bad, but I still went on my morning 30-minute walk. When I arrived home, I took a bath and crawled right back into bed. I thought I was coming down with a cold. I took a COVID-19 test. It came up negative, and I did not have a fever. The next day I felt the same, and I worked from home. The day later, I jumped out of bed and went straight to work. While putting on my makeup, I noticed my eyes looked very dull. For the rest of the day, I pretty much felt the same, with some decreasing energy levels. The white part of my eyes was a yellow color. It did not alert me because it was so light, and moreover, they just were not white. The day after that, by mid-morning at work, the right side under my rib cage hurt. I thought I hurt my back, but it hurt from my back through the front. I had some Tylenol, but it did not help. So I went home early. It was Friday night, and I was making dinner, drinking a glass of wine, and even before finishing the dinner, I went back to bad. I tried researching what was wrong with me because I did not feel it was the flu and my COVID-19 test was negative. I realized my liver was under my right rib, and the pain I was having was because it was swollen. My head was hurting because my liver was not processing toxins, and they were building up. I took more NAC and began drinking Pedialyte. The next day was my worst day, and I doubled down on the NAC by about 3 grams and then took raw organic crushed garlic. About 4 cloves 3 times throughout the day. I felt my liver reduce in size. The garlic drastically helped, so I did it again. I was feeling better. Until now, each day, I have improved. The pressure in my head is almost 90 percent gone. I can still feel my liver is tender, but there is a huge improvement. My joints are still a little achy when I first wake up, but they are better. What happened to me? Did donating blood set something in motion, or was that just a coincidence? I checked with the blood bank, and my blood was fine; and they do check if you have hepatitis. I was also vaccinated for hepatitis years ago. I have not drunk any alcohol for about two weeks now and certainly would not until I feel 100 percent or ever again, possibly. I would say I feel about 75 percent recovered, but it has been a few weeks, and I am worried I am only keeping it at bay, and it is not healing as fast as I would like it to. I still have some fatigue and soreness where my liver is. Here is a list of the supplements I was taking prior and then a list of what I am now taking:

Turmeric with piperine.

Vitamin E.

NAC.

Coenzyme Q10.

Wild caught cod oil.

Magnesium.

Probiotic.

Nutritional yeast.

B-complex two times a week.

Now I take:

NAC 800 mg.

Vitamin A naturally sourced with tocopherols 268 mg.

Milk Thistle extract 1000 mg.

Zinc.

Gallbladder formula (only 1 of the recommended three caps daily).

Zeolite in my electrolyte water.

For about a year now, I have eaten a very low-carbohydrate healthy diet. Only grass-fed or wild-caught protein unless at an event or dinner. Only organic or homegrown. I sprout and use microgreens from my kitchen during a meal most days. In a year, I might fast two times for three days. I always drink my electrolytes during those times and take my vitamins. Now I feel like I have to eat very small portions of food, like only a couple of bites, and stop. I have added back into my diet some berries and root vegetables with the occasional grain, more like a Mediterranean diet. I cannot think of anything I have left out except I do not have any medical conditions or use any prescription medications. My blood pressure was higher than normal for me when I gave blood. It was 130/75 mmHg. I randomly throughout the year check my glucose levels because of a family history of diabetes and stroke. It is always great at 60-80 mg/dL.

Answered by Dr. Ghulam Fareed

Hello,

Welcome to icliniq.com.

I have read your query and will respond.

Patient's Query

Hello doctor,

Sure.

Answered by Dr. Ghulam Fareed

Hello,

Welcome back to icliniq.com.

I have reviewed your case history in detail. You have provided an extensive history mentioning each and every detail. First, I will list the issues I have noticed and then address them one by one.

1) Generalized weakness and morning joint pain or stiffness.

2) Occasionally alcohol consumption initially, then usually a few days a week, and then you have four drinks in almost 6 hours timeframe.

3) You donated blood recently and were worried whether it was related to this or not.

4) Now, the important point is that your health deteriorated initially over a few weeks with fatigue, weakness, yellow color eyes to some extent, and right upper abdominal pain as well.

5) you are on multiple medications and supplements.

6) You have a stressful job and lifestyle.

Now I will give my suggestions, one by one.

1) Before starting this episode, you had some history related to muscle stiffness, so monitor morning stiffness specifically, small joints of hands or large joints like knees or elbows, etc. Duration of stiffness is important too. For this purpose, you should be checked for vitamin D deficiency, rheumatoid factor, and anti-CCP (cyclic citrullinated peptide test) for rheumatoid arthritis.

2) Occasionally, alcohol consumption is fine as per recent guidelines on alcohol liver disease, but daily or binge drinking can be dangerous. So take care of yourself and restrict yourself to occasional alcohol consumption.

3) Well, your symptoms are nothing to do with blood donations as such. They must have checked your hemoglobin before taking your donation, so a single unit of blood in an otherwise healthy person will not cause the symptoms that you are experiencing.

4) Coming to your current issue, this seems to be alcoholic hepatitis secondary to the binge drinking you had the day you traveled. Alcoholic hepatitis is well known clinical entity, and your symptoms can be explained by this, your unwell condition followed by some yellow discoloration of the eyes and right upper abdominal pain. In this situation, you must stop alcohol absolutely and get yourself checked, especially liver function tests and ultrasound of the liver.

The basic step of managing any form of hepatitis is to avoid a trigger and give rest to the liver by not having any hepatotoxic or unusual, or unprescribed drugs. When you do that, it starts getting better because it has the potential to recover on its own in mild to moderate cases. So for this, the only effective medicine you had was NAC (and I am hoping it was N-acetyl cysteine).

5) You are on multiple supplements, which should be avoided if not prescribed by the concerned doctor. One can use supplements for a shorter period of time, like a month or so. These medicines should not be part and parcel of your daily routine. Because at the end of the day, these are medicines, not food, and medicine has some side effects too. So, if you are using supplements on your own, try to cut them down if possible.

6) Avoid stressful situations related to your job or relationship, and try to get some time for yourself too.

Please refrain from taking Paracetamol until you feel fine or get your liver function test done.

I hope I have answered your concerns in detail. Feel free to ask any questions you have.

Take care.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Ghulam Fareed
Dr. Ghulam Fareed

Medical Gastroenterology

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