What factors should be taken into account when using multiple medications?

Hello doctor,

I am currently taking various medications and supplements and would like to check for any interactions and spacing recommendations. I take Levothyroxine 50 mcg first thing in the morning, followed by breakfast and subsequent intake of Metronidazole, Doxycycline, and Hydroxychloroquine. Are these medicines safe to be taken together, and are there any interactions between hydroxychloroquine and these antibiotics? I then take a prenatal vitamin, vitamin D3, vitamin E, omega-3, vitamin C, Lactoferrin, and Ubiquinone enzyme. Are these supplements compatible with the medication? While I am aware that Doxycycline should not be taken with iron, calcium, or zinc, are the others acceptable? I plan to adjust the timing of Doxycycline to take it before breakfast to avoid interference with the prenatal vitamin. How soon after taking Thyroxine can I take antibiotics, and is there a recommended time gap? Kindly advice.

Thank you for the reply doctor,

I usually have breakfast around eight in the morning and lunch around one o'clock in the afternoon. Is it okay to take the other vitamins with breakfast, or should I take the multivitamin some time after the morning meal? Typically, I am not at home during lunch. Kindly suggest.

Thanks for the reply doctor,

I take Doxycycline and Hydroxychloroquine twice a day, and Metronidazole three times a day. Additionally, I need to take vitamins due to deficiencies. I prefer taking them in the morning to avoid impacting my sleep. Could you please clarify why I need to wait 30 to 40 minutes after food to take supplements? The instructions advise taking them with food. My doctor mentioned that Hydroxychloroquine can be taken with vitamins. I was under the impression that the only potential interaction was between Doxycycline and iron, calcium, and zinc, which are included in my multivitamin. Therefore, I thought that by taking Doxycycline earlier, waiting for two hours, and then having my breakfast, all my vitamins and Hydroxychloroquine would be okay. Could you provide some clarification on this?

Thanks for the prompt reply doctor,

I have been on antibiotics for just ten days. The other medications are part of my permanent regimen, and I have been taking them for the past six months. During my new routine, I plan to take Thyroxine upon waking, wait for 45 minutes, and then take both Doxycycline and Metronidazole together. Following this, I will have breakfast an hour later, and 30 minutes after breakfast, I will take all of my vitamins and Hydroxychloroquine. This schedule is designed to allow sufficient time for all the medications to take effect. Kindly provide your opinion.