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I have chronic fatigue with positive EBV. What should I do further?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I have had problems with chronic fatigue for the past 10 years. I was reading about EBV and the test came back positive. Can you review the attached report and give me analysis and next steps as far as testing and treatment?

Answered by Dr. Goswami Parth Rajendragiri

Education:

MBBS

Professional Bio:

Dr. Goswami Parth Rajendragiri is an experienced General Physician and Pathologist with extensive years of clinical expertise. He specializes in diagnosing and managing a wide range of medical conditions while providing holistic care to patients. As a Pathologist, he is skilled in performing and interpreting laboratory investigations that aid in accurate diagnosis and treatment planning. Dr. Rajendragiri is dedicated to delivering patient-focused care with a strong emphasis on preventive medicine and overall well-being.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I have seen the report (attachment removed to protect patient identity).

The positive IgG report can be due to past infection as well. To rule out recent infection, you need to investigate with IgM antibody estimation against EBV (Epstein-Barr virus).

Kindly mention if you have a sore throat, enlarged neck node, enlarged spleen like presentation,etc.? No specific treatment is needed for EBV induced mononucleosis infection.

For your weakness, investigate with ANA (antinuclear antibody) estimation, and neurological examination is also advisable.

Patient's Query

Thank you doctor,

My concern is that I am having a reactivation of the EBV. Can this be the case and is there another test to confirm or deny?

Answered by Dr. Goswami Parth Rajendragiri

Education:

MBBS

Professional Bio:

Dr. Goswami Parth Rajendragiri is an experienced General Physician and Pathologist with extensive years of clinical expertise. He specializes in diagnosing and managing a wide range of medical conditions while providing holistic care to patients. As a Pathologist, he is skilled in performing and interpreting laboratory investigations that aid in accurate diagnosis and treatment planning. Dr. Rajendragiri is dedicated to delivering patient-focused care with a strong emphasis on preventive medicine and overall well-being.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome back to icliniq.com.

As I have mentioned in my answer, IgG antibody positivity to VCA can be due to past infection of EBV. IgG antibody can be positive for many years after acute infection.

But to confirm reactivation or acute infection you can investigate with IgM antibody test. So you can investigate with IgM testing against EBV. IgM antibody if positive, it does not indicate an old infection. It can be due to recent infection only at least within the last few months. Clinical correlation also should be done.

I hope this helps.

Medically reviewed by Dr. Vinodhini J.
Published At September 29, 2020
Reviewed At July 27, 2023

Education:

MBBS

Professional Bio:

Dr. Goswami Parth Rajendragiri is an experienced General Physician and Pathologist with extensive years of clinical expertise. He specializes in diagnosing and managing a wide range of medical conditions while providing holistic care to patients. As a Pathologist, he is skilled in performing and interpreting laboratory investigations that aid in accurate diagnosis and treatment planning. Dr. Rajendragiri is dedicated to delivering patient-focused care with a strong emphasis on preventive medicine and overall well-being.

This doctor is not available for online consultations on the platform anymore.

Education:

BDS

Professional Bio:

Dr. Vinodhini J. is a Dental Surgeon with extensive years of clinical experience. She specializes in the diagnosis, prevention, and treatment of dental and oral health issues, including restorative, surgical, and cosmetic procedures. With a patient-centered approach, she focuses on maintaining oral health, alleviating discomfort, and enhancing smiles. Her expertise ensures comprehensive care tailored to each patient’s dental needs and overall wellbeing.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Goswami Parth Rajendragiri is an experienced General Physician and Pathologist with extensive years of clinical expertise. He specializes in diagnosing and managing a wide range of medical conditions while providing holistic care to patients. As a Pathologist, he is skilled in performing and interpreting laboratory investigations that aid in accurate diagnosis and treatment planning. Dr. Rajendragiri is dedicated to delivering patient-focused care with a strong emphasis on preventive medicine and overall well-being.

This doctor is not available for online consultations on the platform anymore.

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