HomeAnswersRheumatologyerythrocyte sedimentation rateWhy are my erythrocyte sedimentation rate and C-reactive protein levels elevated?

Do elevated erythrocyte sedimentation rate and C-reactive protein levels suggest cancer?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At January 12, 2023
Reviewed AtJune 8, 2023

Patient's Query

Hello doctor,

I had undergone a few test reports for erythrocyte sedimentation rate and C-reactive protein. The reports suggested a very high sedimentation rate and elevated C-reactive protein levels. Why so? I am also worried of having a cancer.

Please help.

Hello,

Welcome to icliniq.com.

I went through your query and understood your concern.

I went through your reports (the attachment removed to protect the patient's identity). ESR (erythrocyte sedimentation rate) and CRP (C-reactive protein) are nonspecific tests. They can rise in just a viral infection. Raised ESR and CRP do not lead to the diagnosis of cancer. I suggest you might be having some autoimmune disorder. I would suggest you get a biopsy of your erythematous spots. I also suggest you repeat ESR and CRP after three weeks.

I hope this has helped you.

Thanks and regards.

Patient's Query

Hello doctor,

Thanks for replying.

I forgot to inform you that I had a pretty bad viral infection a few weeks back. I had a cough, a fever, and bad myalgias in my arms and legs. The erythematous spots on the roof of my mouth started when the myalgias subsided and resolved after about three weeks. I have no symptoms currently.

I have a few questions for you:

1). Can an oral lichenoid reaction (white Wickham striae on the side of my cheek inside my mouth, which on biopsy was proven to be a lichenoid reaction) cause an elevated sedimentation rate and C-reactive protein because I still have the oral lichenoid reaction?

2). I got my blood reports after the viral infection. Could this be the cause of my elevated sedimentation rate and C-reactive protein?

3). Why do you say that it is not cancer? Are the values typically higher in cancer?

Please help.

Hello,

Welcome back to icliniq.com.

As I suggested, high CRP and ESR are nonspecific tests. You can even get them raised in the common cold. The answer to your specific queries are,

1. Yes, as the diagnosis in itself says "reaction," so CRP and ESR are markers of inflammatory reaction. Your values are not very high, so we can get these values in a lichenoid reaction.

2. Following any viral infection, CRP and ESR may remain elevated for months.

3. These are nonspecific tests and can be raised in cancer too. But there has to be a reason to say it could be cancer.

I, therefore, suggest you rule out basic diseases first before jumping to big names like cancer.

I hope this has helped you.

Thanks and regards.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Anshul Varshney
Dr. Anshul Varshney

Internal Medicine

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