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HomeAnswersAnesthesiologygeneral anesthesiaDo I have pseudocholinesterase deficiency based on the blood results?

Do I have pseudocholinesterase deficiency based on the blood results?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Answered by

Dr. Sukhdev Garg

Medically reviewed by

iCliniq medical review team

Published At February 13, 2018
Reviewed AtJanuary 9, 2023

Patient's Query

Hello doctor,

I am hoping someone can tell me if I have pseudocholinesterase deficiency based on the blood results below? My father has it and found out the hard way after surgery. His sister also has it. The results from my blood test were:

  • Cholinesterase, serum Result: 2228 L Reference range: 2673-6592 IU/L
  • Cholinesterase W/DIB INH cholinesterase, serum Result: 2228 L Reference range: 2673-6592 IU/L
  • Dibucaine number Result: 81.3 L Reference range: 81.6-88.3 % Inhibit
Answered by Dr. Sukhdev Garg


Welcome to icliniq.com.

You may have atypical pseudocholinesterase deficiency due to a heterozygous mutation which is hereditary. Pseudocholinesterase is an enzyme responsible for the metabolism of certain anesthetic drugs like succinylcholine and ester group of local anesthetics.

Your Dibucaine number is 81 that is quite normal. But still, some drugs can be avoided if you require anesthesia. It is not like you cannot have a surgery. If you have a surgery in the future, please tell your anesthetist about this so he will be more careful in choosing drugs.

I hope this lessens your worries to some extent.

For more information consult an anesthesiologist online --> https://www.icliniq.com/ask-a-doctor-online/anesthesiologist

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Sukhdev Garg
Dr. Sukhdev Garg


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